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δ-9-四氢大麻酚改善癌症化疗引起的恶心和呕吐。

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol.

作者信息

Ekert H, Waters K D, Jurk I H, Mobilia J, Loughnan P

出版信息

Med J Aust. 1979 Dec 15;2(12):657-9.

PMID:231736
Abstract

The antinausea and antivomiting effects of delta-9-tetrahydrocannabinol (THC) in children receiving cancer chemotherapy were compared with those of metoclopramide syrup and prochlorperazine tablets in two double-blind studies. THC was found to be a significantly better antinausea and antivomiting agent, but not all patients obtained relief of nausea and vomiting with THC. In some patients, THC enhanced appetite during a course of chemotherapy. In two patients, a "high" associated with THC administrationwas reported. Drowsiness was reported significantly more frequently with THC.

摘要

在两项双盲研究中,对接受癌症化疗的儿童使用δ-9-四氢大麻酚(THC)的抗恶心和止吐效果与甲氧氯普胺糖浆和丙氯拉嗪片进行了比较。结果发现,THC是一种明显更好的抗恶心和止吐药物,但并非所有患者使用THC后恶心和呕吐都能得到缓解。在某些患者中,THC在化疗过程中增强了食欲。有两名患者报告出现了与使用THC相关的“兴奋感”。使用THC后嗜睡的报告明显更频繁。

相似文献

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Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol.δ-9-四氢大麻酚改善癌症化疗引起的恶心和呕吐。
Med J Aust. 1979 Dec 15;2(12):657-9.
2
Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine.接受癌症化疗患者使用的止吐药:Δ⁹-四氢大麻酚与丙氯拉嗪的随机对照比较
N Engl J Med. 1980 Jan 17;302(3):135-8. doi: 10.1056/NEJM198001173020302.
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Nabilone and high-dose metoclopramide: anti-emetics for cancer chemotherapy.
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Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy.地塞米松的止吐疗效。在接受癌症化疗的患者中与丙氯拉嗪进行的随机、双盲、交叉研究。
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Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.奈必洛尔与丙氯拉嗪用于控制儿童癌症化疗引起的呕吐:一项双盲交叉试验。
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Prevention of chemotherapy-induced nausea and vomiting in patients with cancer.癌症患者化疗引起的恶心和呕吐的预防
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