Sallan S E, Cronin C, Zelen M, Zinberg N E
N Engl J Med. 1980 Jan 17;302(3):135-8. doi: 10.1056/NEJM198001173020302.
Delta-9-tetrahydrocannabinol (THC) is an effective antiemetic as compared with placebos in patients receiving chemotherapy for cancer. In this study we compared THC with prochlorperazine (compazine) in a randomized, double-blind, crossover trial with patients who had failed to benefit from standard antiemetic therapy. Regardless of the emetic activity of the chemotherapeutic agents, there were more complete responses to THC courses (in 36 of 79 courses) than to prochlorperazine (in 16 of 78 courses). Of 25 patients who were treated with both drugs and who expressed a preference, 20 preferred THC (P = 0.005). Among patients under 20 years of age there was a higher proportion of complete responses to THC courses (15 of 20) than among older patients (21 of 59 courses; P = 0.004). Increased food intake occurred more frequently with THC (P = 0.008) and was associated with the presence of a "high." Of 36 THC courses resulting in complete antiemetic responses, 32 were associated with a high. We conclude that THC is an effective antiemetic in many patients who receive chemotherapy for cancer and for whom other antiemetics are ineffective. (N Engl J Med 302:135--138, 1980).
与安慰剂相比，Δ-9-四氢大麻酚（THC）对接受癌症化疗的患者是一种有效的止吐药。在本研究中，我们在一项随机、双盲、交叉试验中，将THC与丙氯拉嗪（康帕嗪）进行比较，受试患者为那些未能从标准止吐疗法中获益的患者。无论化疗药物的致吐活性如何，THC疗程的完全缓解率（79个疗程中有36个）高于丙氯拉嗪（78个疗程中有16个）。在同时接受两种药物治疗并表达了偏好的25例患者中，20例更喜欢THC（P = 0.005）。在20岁以下的患者中，THC疗程的完全缓解率（20个疗程中有15个）高于老年患者（59个疗程中有21个；P = 0.004）。THC使食物摄入量增加的情况更频繁（P = 0.008），且与“兴奋感”的出现有关。在36个产生完全止吐反应的THC疗程中，32个与兴奋感有关。我们得出结论，对于许多接受癌症化疗且其他止吐药无效的患者，THC是一种有效的止吐药。（《新英格兰医学杂志》302:135 - 138, 1980）
