Department of General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
BMC Cancer. 2012 Nov 23;12:545. doi: 10.1186/1471-2407-12-545.
Obesity has been associated with increased incidence of colorectal cancer. Adipose tissue dysfunction accompanied with alterations in the release of adipocytokines has been proposed to contribute to cancer pathogenesis and progression. The aim of this study was to analyze plasma concentrations of several adipose tissue expressed hormones in colorectal cancer patients (CRC) and morbidly obese (MO) patients and to compare these concentrations to clinicopathological parameters.
Plasma concentrations of adiponectin, resistin, leptin, active plasminogen activator inhibitor (PAI)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-1 alpha, and tumor necrosis factor (TNF)-alpha were determined in 67 patients operated on for CRC (31 rectal cancers, 36 colon cancers), 37 patients operated on for morbid obesity and 60 healthy blood donors (BD).
Compared to BD, leptin concentrations were lowered in CRC patients whereas those of MO patients were elevated. Adiponectin concentrations were only lowered in MO patients. Concentrations of MCP-1, PAI-1, and IL-1 alpha were elevated in both CRC and MO patients, while resistin and TNF-alpha were similarly expressed in MO and CRC patients compared to BD. Resistin concentrations positively correlated with tumor staging (p<0.002) and grading (p=0.015) of rectal tumor patients.
The results suggest that both MO and CRC have low-grade inflammation as part of their etiology.
肥胖与结直肠癌发病率的增加有关。脂肪组织功能障碍伴随着脂肪细胞因子释放的改变，被认为是导致癌症发生和发展的原因。本研究的目的是分析结直肠癌（CRC）患者和病态肥胖（MO）患者血浆中几种脂肪组织表达激素的浓度，并将这些浓度与临床病理参数进行比较。
在 67 例接受手术治疗的 CRC 患者（31 例直肠癌，36 例结肠癌）、37 例接受 MO 手术治疗的患者和 60 例健康献血者（BD）中，测定了血浆中脂联素、抵抗素、瘦素、活性纤溶酶原激活物抑制剂（PAI）-1、单核细胞趋化蛋白（MCP）-1、白细胞介素（IL）-1α和肿瘤坏死因子（TNF）-α的浓度。
与 BD 相比，CRC 患者的瘦素浓度降低，而 MO 患者的瘦素浓度升高。脂联素浓度仅在 MO 患者中降低。MCP-1、PAI-1 和 IL-1α的浓度在 CRC 和 MO 患者中均升高，而抵抗素和 TNF-α在 MO 和 CRC 患者中的表达与 BD 相似。抵抗素浓度与直肠肿瘤患者的肿瘤分期（p<0.002）和分级（p=0.015）呈正相关。
这些结果表明，MO 和 CRC 都存在低度炎症，这是其病因的一部分。
