他汀类药物在下肢动脉疾病中的应用：综述
Use of statins in lower extremity artery disease: a review.
作者信息
Gargiulo Giuseppe, Giugliano Giuseppe, Brevetti Linda, Sannino Anna, Schiattarella Gabriele Giacomo, Serino Federica, Carbone Andreina, Scudiero Fernando, Ferrone Marco, Corrado Roberto, Izzo Raffaele, Chiariotti Lorenzo, Perrino Cinzia, Amato Bruno, Trimarco Bruno, Esposito Giovanni
机构信息
Department of Clinical Medicine and Cardiovascular and Immunology Sciences, Federico II University, via Pansini 5, 80131 Naples, Italy.
出版信息
BMC Surg. 2012;12 Suppl 1(Suppl 1):S15. doi: 10.1186/1471-2482-12-S1-S15. Epub 2012 Nov 15.
BACKGROUND
Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk.
DESCRIPTION
It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached.
CONCLUSIONS
Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.
背景
下肢动脉疾病（LE-PAD）是动脉粥样硬化最常见的表现之一，尤其是在老年患者中，并且它与高心血管风险相关。
描述
他汀类药物治疗通过限制动脉粥样硬化进展、减少心血管事件和死亡率，对心血管系统具有关键益处，这一点已得到充分证实。越来越多的证据支持他汀类药物在LE-PAD中的疗效，因为其既能降低心血管风险，又能改善步行距离，从而提高生活质量。因此，所有LE-PAD患者都应考虑使用他汀类药物治疗，并应达到新的低密度脂蛋白胆固醇目标。
结论
我们认为他汀类药物治疗仍未得到充分利用或剂量不足，因此应改进LE-PAD患者的治疗，以获得他汀类药物已证实的所有益处。
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