Lechleitner M
Landeskrankenhaus Hochzirl, Anna-Dengel-Haus, 6170 Zirl, Österreich.
Z Gerontol Geriatr. 2013 Aug;46(6):577-85; quiz 586-7. doi: 10.1007/s00391-013-0516-6.
Cardiovascular disease is also the most frequent cause of mortality in the elderly population. Invasive diagnostic and therapeutic interventions are performed at an increasing rate in older patients in order to maintain functional capacities and, thus, an adequate quality of life. Thus, strategies to prevent cardiovascular events (e.g., lipid lowering therapy) are also of great importance in elderly. With respect to the side effects of statin therapy, the risk of drug interaction has to be considered, as well as myopathy. Discrepant study results exist about the influence of statins on cognitive function. Retrospective analyses indicate that statin therapy might be related to an increased risk for type.2 diabetes in certain risk groups. The indication for statin therapy should, therefore, consider the risk profile and especially the individual situation of the older patient.
心血管疾病也是老年人群中最常见的死亡原因。为了维持功能能力并进而保持足够的生活质量，侵入性诊断和治疗干预在老年患者中的实施率正在不断提高。因此，预防心血管事件的策略（如降脂治疗）在老年人中也非常重要。关于他汀类药物治疗的副作用，必须考虑药物相互作用的风险以及肌病。关于他汀类药物对认知功能的影响，存在不一致的研究结果。回顾性分析表明，他汀类药物治疗可能与某些风险组中2型糖尿病风险增加有关。因此，他汀类药物治疗的适应症应考虑风险状况，尤其是老年患者的个体情况。
