Lagenstein I, Willig R P, Kühne D
Neuropadiatrie. 1979 Nov;10(4):370-84. doi: 10.1055/s-0028-1085339.
8 children with different petit mal epilepsies were systematically treated with ACTH and dexamethasone. CCT examinations were performed before, during and after treatment. In all children severe cerebral changes. enlargement of ventricles and subarachnoid space developed during the initial phase of treatment with Depot-ACTH. Similar changes, but to a less severe degree, could be demonstrated during the phase of dexamethasone therapy thereafter. In all patients cerebral changes disappeared after hormonal treatment had ended. At this point many children had a developmental spurt, developmental relapses could not be observed. It is suggested that these reversible changes seen on CCT scans represent a form of morphological plasticity of brain structures. These results bear certain consequences as to the therapy of cerebral edema.
8名患有不同类型小发作癫痫的儿童接受了促肾上腺皮质激素（ACTH）和地塞米松的系统治疗。在治疗前、治疗期间和治疗后进行了计算机断层扫描（CCT）检查。在所有儿童中，使用长效促肾上腺皮质激素治疗初期出现了严重的脑部变化、脑室扩大和蛛网膜下腔增宽。在随后的地塞米松治疗阶段也出现了类似变化，但程度较轻。在激素治疗结束后，所有患者的脑部变化均消失。此时许多儿童出现了发育加速，未观察到发育倒退。提示CCT扫描所见的这些可逆性变化代表了脑结构的一种形态可塑性形式。这些结果对脑水肿的治疗具有一定的意义。
