Department of Chemistry, MS 60, Rice University, 6100 Main Street, Houston, TX - 77005, USA.
Chem Commun (Camb). 2013 May 14;49(39):4166-8. doi: 10.1039/c2cc37323h. Epub 2012 Nov 23.
A simple rhodium(II) complex catalyzes cysteine modification with diazo reagents. The reaction is marked by clean cysteine selectivity and mild reaction conditions. The resulting linkage is significantly more stable in human plasma serum, when compared to common maleimide reagents.
一种简单的二价铑配合物可以催化含重氮试剂的半胱氨酸修饰。该反应具有明显的半胱氨酸选择性和温和的反应条件。与常见的马来酰亚胺试剂相比，生成的键在人血浆血清中显著更稳定。
