快速全基因组测序在疑似结核病暴发调查中的应用。
Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak.
机构信息
Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
出版信息
J Clin Microbiol. 2013 Feb;51(2):611-4. doi: 10.1128/JCM.02279-12. Epub 2012 Nov 21.
Abstract
Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.
摘要
两名在英国同一所学校就读的东南亚学生患有肺结核。流行病学调查未能将这两例病例联系起来，且结核分枝杆菌分离株的耐药谱存在差异。分离株的全基因组测序发现它们在基因上完全相同，提示存在漏传事件。
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