Słońska Anna, Polowy Rafał, Golke Anna, Cymerys Joanna
Zakład Wirusologii, Katedra Nauk Przedklinicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie-SGGW, ul. Ciszewskiego 8, 02-786 Warszawa, Poland.
Postepy Hig Med Dosw (Online). 2012 Oct 30;66:810-7. doi: 10.5604/17322693.1016360.
Cytoskeleton, composed of actin filaments, microtubules and intermediate filaments, regulates many processes in the cell, e.g. intracellular transport. Actin and microtubules are polarized structures, along which bidirectional transport of motor proteins occurs: myosins along actin and the dynein/dynactin complex and kinesins along microtubules. Viruses interact with the cytoskeleton and motor proteins at different stages during their replication cycle. When entering and egressing the cell, viruses must penetrate the cortical layer of microfilaments, which usually takes place with the contribution of myosin. In the cytoplasm, retrograde transport involving dynein is used to move viruses to the microtubule organizing center. After replication, kinesins participate in anterograde transport of newly produced virions to the peripheral region, close to the plasma membrane. Some families of viruses have developed alternate routes of intracellular transport. The aim of this study is to describe the interactions between virus and cytoskeletal motor proteins and to determine their role in viral infection according to the current literature data.
细胞骨架由肌动蛋白丝、微管和中间丝组成，调控细胞内的许多过程，如细胞内运输。肌动蛋白和微管是极化结构，沿其发生驱动蛋白的双向运输：肌球蛋白沿肌动蛋白运输，动力蛋白/动力蛋白激活蛋白复合体和驱动蛋白沿微管运输。病毒在其复制周期的不同阶段与细胞骨架和驱动蛋白相互作用。进出细胞时，病毒必须穿透微丝的皮质层，这通常在肌球蛋白的作用下发生。在细胞质中，涉及动力蛋白的逆行运输用于将病毒转运至微管组织中心。复制后，驱动蛋白参与将新产生的病毒粒子顺行运输至靠近质膜的周边区域。一些病毒家族已形成细胞内运输的替代途径。本研究的目的是根据当前文献数据描述病毒与细胞骨架驱动蛋白之间的相互作用，并确定它们在病毒感染中的作用。
