Feuerstein I A, Ratner B D
Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Biomaterials. 1990 Mar;11(2):127-32. doi: 10.1016/0142-9612(90)90128-d.
Five materials of interest in blood contact applications (PVC, Silastic, Biomer and siliconized glass) were internally coated on glass tubes and exposed to suspensions of platelets and red cells. Uncoated glass was also examined. Thrombin was added (prestimulation) to some suspensions before exposure to the biomaterial surfaces. The three polymeric surfaces were characterized by electron spectroscopy for chemical analysis (ESCA). Prestimulation with thrombin leads to increased adhesion of single platelets only with Silastic. With a wide range of surface types, thrombin prestimulation consistently leads to higher levels of platelet accumulation in the form of aggregates; the PVC-coated material showed the highest levels. ESCA analysis of PVC, however, suggested our coating was impure or an oxidized material.
五种在血液接触应用中感兴趣的材料（聚氯乙烯、硅橡胶、生物材料和硅化玻璃）被内涂覆在玻璃管上，并暴露于血小板和红细胞悬液中。未涂覆的玻璃也进行了检查。在暴露于生物材料表面之前，向一些悬液中加入凝血酶（预刺激）。通过电子能谱化学分析（ESCA）对三种聚合物表面进行了表征。凝血酶预刺激仅导致硅橡胶上单个血小板的粘附增加。在多种表面类型中，凝血酶预刺激始终导致以聚集体形式存在的血小板聚集水平更高；聚氯乙烯涂层材料的水平最高。然而，对聚氯乙烯的ESCA分析表明我们的涂层不纯或为氧化材料。
