Eatroff Adam E, Langston Cathy E, Chalhoub Serge, Poeppel Karen, Mitelberg Eleonora
Bobst Hospital, The Animal Medical Center, 510 E 62nd St, New York, NY 10065, USA.
J Am Vet Med Assoc. 2012 Dec 1;241(11):1471-8. doi: 10.2460/javma.241.11.1471.
To determine the long-term outcome for small animal patients with acute kidney injury (AKI) treated with intermittent hemodialysis (IHD).
Retrospective case series.
42 cats and 93 dogs treated with IHD for AKI.
Medical records of cats and dogs treated with IHD for AKI from January 1997 to October 2010 were reviewed. Standard methods of survival analysis with Kaplan-Meier product limit curves were used. The log-rank, Mann-Whitney, and Kruskal-Wallis tests were used to determine whether outcome, number of IHD treatments, or duration of hospitalization was different when dogs and cats were classified according to specific variables.
The overall survival rate at the time of hospital discharge was 50% (21/42) for cats and 53% (49/93) for dogs. The overall survival rate 30 days after hospital discharge was 48% (20/42) for cats and 42% (39/93) for dogs. The overall survival rate 365 days after hospital discharge was 38% (16/42) for cats and 33% (31/93) for dogs. For all-cause mortality, the median survival time was 7 days (95% confidence interval, 0 to 835 days) for cats and 9 days (95% confidence interval, 0 to 55 days) for dogs.
Cats and dogs with AKI treated with IHD have survival rates similar to those of human patients. Although there was a high mortality rate prior to hospital discharge, those patients that survived to discharge had a high probability of long-term survival.
确定接受间歇性血液透析（IHD）治疗的小动物急性肾损伤（AKI）患者的长期预后。
回顾性病例系列。
42只猫和93只狗接受IHD治疗AKI。
回顾1997年1月至2010年10月接受IHD治疗AKI的猫和狗的病历。采用Kaplan-Meier乘积限界曲线的标准生存分析方法。当根据特定变量对猫和狗进行分类时，使用对数秩检验、Mann-Whitney检验和Kruskal-Wallis检验来确定预后、IHD治疗次数或住院时间是否存在差异。
出院时猫的总体生存率为50%（21/42），狗为53%（49/93）。出院后30天猫的总体生存率为48%（20/42），狗为42%（39/93）。出院后365天猫的总体生存率为38%（16/42），狗为33%（31/93）。对于全因死亡率，猫的中位生存时间为7天（95%置信区间，0至835天），狗为9天（95%置信区间，0至55天）。
接受IHD治疗的AKI猫和狗的生存率与人类患者相似。尽管出院前死亡率较高，但存活至出院的患者有较高的长期存活概率。
