9号染色体短臂在转移性卵巢腺癌中的作用。

Involvement of 9p in metastatic ovarian adenocarcinomas.

作者信息

Bello M J, Moreno S, Rey J A

机构信息

Instituto de Investigaciones Biomédicas del CSIC, Madrid, Spain.

出版信息

Cancer Genet Cytogenet. 1990 Apr;45(2):223-9. doi: 10.1016/0165-4608(90)90086-p.

DOI:10.1016/0165-4608(90)90086-p

PMID:2317770

Abstract

By a direct method and after in vitro culture, we cytogenetically analyzed five ovarian adenocarcinomas, using six samples of ascitic fluid. The structural aberrations included rearrangements of chromosomes 1 and 3, in agreement with the results of other researchers. The long arm of chromosome 6 was rearranged in three samples, but no translocation t(6;14) was found. Rearrangements involving 9p were present in all cases, with breakpoints at p13 or p22-23.

摘要

通过直接法并经体外培养后，我们使用六份腹水样本对五例卵巢腺癌进行了细胞遗传学分析。结构畸变包括1号和3号染色体的重排，这与其他研究人员的结果一致。6号染色体长臂在三个样本中发生重排，但未发现t(6;14)易位。所有病例均存在涉及9p的重排，断点位于p13或p22 - 23。