Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University, Medical School, Athens, Greece.
Cytokine. 2013 Feb;61(2):591-4. doi: 10.1016/j.cyto.2012.10.029. Epub 2012 Nov 22.
To investigate possible alterations in cord blood levels of adipokine nesfatin-1 (secreted by adipose tissue and pancreatic β-cells and implicated in glucose metabolism and insulin resistance), as well as insulin, in large (LGA) and appropriate for gestational age (AGA) pregnancies, granted that these groups differ in body fat mass and metabolic/endocrine mechanisms.
Cord blood nesfatin-1 and insulin concentrations were prospectively measured in 40 LGA (9 born from diabetic and 31 from non-diabetic mothers) and 20 AGA singleton full-term infants as well as their mothers.
Cord blood nesfatin-1 concentrations were significantly lower in LGA compared to AGA neonates (b=-0.206, SE 0.07, p=0.005). However, cord blood nesfatin-1 concentrations were elevated in infants born from mothers with gestational diabetes mellitus (GDM), compared to those born from non-diabetic mothers, after controlling for group (b=0.190, SE 0.10, p=0.05). Finally, cord blood nesfatin-1 concentrations were lower in cases of vaginal delivery (b=0.11, SE 0.05, p=0.042). Insulin levels were significantly elevated, as customized centiles increased (b=0.004, SE=0.002, p=0.016). No significant correlation was found between insulin and nesfatin-1 in maternal and umbilical cord levels.
In this study nesfatin-1 levels are decreased in LGA compared to AGA fetuses. Fetal nesfatin-1 concentrations are higher in cases of GDM and cord blood nesfatin-1 concentrations are lower in cases of vaginal delivery.
研究脐血中脂肪因子 nesfatin-1（由脂肪组织和胰岛β细胞分泌，与葡萄糖代谢和胰岛素抵抗有关）和胰岛素水平在巨大儿（LGA）和适于胎龄儿（AGA）中的可能变化，因为这两组在体脂质量和代谢/内分泌机制上有所不同。
前瞻性测量了 40 例 LGA（9 例来自糖尿病母亲，31 例来自非糖尿病母亲）和 20 例 AGA 单胎足月婴儿及其母亲的脐血 nesfatin-1 和胰岛素浓度。
与 AGA 新生儿相比，LGA 新生儿脐血 nesfatin-1 浓度显著降低（b=-0.206，SE0.07，p=0.005）。然而，在校正组间差异后，患有妊娠期糖尿病（GDM）的母亲所生婴儿的脐血 nesfatin-1 浓度高于非糖尿病母亲所生婴儿（b=0.190，SE0.10，p=0.05）。最后，阴道分娩时脐血 nesfatin-1 浓度较低（b=0.11，SE0.05，p=0.042）。胰岛素水平随着定制百分位数的增加而显著升高（b=0.004，SE=0.002，p=0.016）。母体和脐带水平的胰岛素与 nesfatin-1 之间未发现显著相关性。
在这项研究中，与 AGA 胎儿相比，LGA 胎儿的 nesfatin-1 水平降低。GDM 病例中胎儿 nesfatin-1 浓度较高，阴道分娩时脐血 nesfatin-1 浓度较低。
