Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 12203 Berlin, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany.
Int J Mol Sci. 2021 Oct 14;22(20):11059. doi: 10.3390/ijms222011059.
Ghrelin and nesfatin-1 are enteroendocrine peptide hormones expressed in rat X/A-like and human P/D1cells of the gastric mucosa. Besides their effect on food intake, both peptides are also implicated in various other physiological systems. One of these is the reproductive system. This present review illustrates the distribution of ghrelin and nesfatin-1 along the hypothalamus-pituitary-gonadal (HPG) axis, their modulation by reproductive hormones, and effects on reproductive functions as well as highlighting gaps in current knowledge to foster further research.
生长激素释放肽和 nesfatin-1 是在大鼠 X/A 样和人胃黏膜 P/D1 细胞中表达的肠内分泌肽激素。除了对摄食的影响外，这两种肽还与各种其他生理系统有关。其中之一是生殖系统。本综述说明了生长激素释放肽和 nesfatin-1 在下丘脑-垂体-性腺 (HPG) 轴中的分布、生殖激素对它们的调节以及对生殖功能的影响，并强调了当前知识空白以促进进一步的研究。
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