Faculty of Pharmaceutical Science, Burapha University, Chonburi, Thailand.
Eur J Pharm Biopharm. 2013 Apr;83(3):315-21. doi: 10.1016/j.ejpb.2012.10.002. Epub 2012 Nov 23.
Clearly understanding of swelling kinetics and erosion behavior of polymer can reveal drug release mechanism and kinetics. Recently, swelling progression and mobility of water molecule inside polymers have been investigated by several technologies, including magnetic resonance imaging (MRI), X-ray microtomography (XμT), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), fluorescent, texture analyzer, and ultrasound techniques. Each technique offers its own advantages which suit to different study purposes. This review describes application of the advanced technologies to monitor swelling-erosion behaviors and also compares pros and cons of each technique. This may help the researchers to select the appropriate technique for their polymer.
清楚了解聚合物的溶胀动力学和侵蚀行为可以揭示药物释放机制和动力学。最近，几种技术包括磁共振成像（MRI）、X 射线微断层扫描（XμT）、傅里叶变换红外光谱（FTIR）、原子力显微镜（AFM）、荧光、质地分析仪和超声技术，已经被用于研究聚合物内部水分子的溶胀进展和迁移。每种技术都有其自身的优势，适用于不同的研究目的。本文综述了这些先进技术在监测溶胀-侵蚀行为中的应用，并比较了每种技术的优缺点。这可能有助于研究人员为他们的聚合物选择合适的技术。
