成年脊椎动物听觉感觉上皮在创伤后的变化。
Changes in the adult vertebrate auditory sensory epithelium after trauma.
机构信息
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, CHDD CD176, Box 357923, Univ. of Washington, Seattle, WA 98195-7923, USA.
出版信息
Hear Res. 2013 Mar;297:91-8. doi: 10.1016/j.heares.2012.11.010. Epub 2012 Nov 20.
Abstract
Auditory hair cells transduce sound vibrations into membrane potential changes, ultimately leading to changes in neuronal firing and sound perception. This review provides an overview of the characteristics and repair capabilities of traumatized auditory sensory epithelium in the adult vertebrate ear. Injured mammalian auditory epithelium repairs itself by forming permanent scars but is unable to regenerate replacement hair cells. In contrast, injured non-mammalian vertebrate ear generates replacement hair cells to restore hearing functions. Non-sensory support cells within the auditory epithelium play key roles in the repair processes.
摘要
听觉毛细胞将声音振动转化为膜电位变化，最终导致神经元放电和声音感知的变化。本文综述了成年脊椎动物听觉感觉上皮中受创伤的听觉感觉上皮的特征和修复能力。受伤的哺乳动物听觉上皮通过形成永久性瘢痕来自我修复，但无法再生替代毛细胞。相比之下，受伤的非哺乳动物脊椎动物耳朵会产生替代毛细胞来恢复听力功能。听觉上皮内的非感觉支持细胞在修复过程中发挥关键作用。
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