高价碘诱导的 12-氧代甾体的准法沃斯基 C 环收缩：通向 C-降甾体的捷径。
Hypervalent-iodine induced quasi-Favorskii C-ring contraction of 12-oxosteroids: a shortcut to C-norsteroids.
机构信息
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México DF, Mexico.
出版信息
Steroids. 2013 Feb;78(2):234-40. doi: 10.1016/j.steroids.2012.11.008. Epub 2012 Nov 23.
Abstract
Treatment of 12-oxosteroids with PhI(OAc)(2) and KOH in refluxing methanol triggers a quasi-Favorskii C-ring contraction leading to the corresponding 11α-alcoxycarbonyl-C-norsteroids in moderate yields. This constitutes the first one-step synthetic alternative to C-norsteroids starting from 12-oxosteroids.
摘要
用 PhI(OAc)(2) 和 KOH 在回流甲醇中处理 12-氧代甾体化合物会引发准 Favorskii C 环收缩，从而以中等收率得到相应的 11α-烷氧基羰基-C-降甾体化合物。这是从 12-氧代甾体化合物开始合成 C-降甾体化合物的第一种一步法替代方法。
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