Takahashi R N, Singer G
Pharmacol Biochem Behav. 1979 Dec;11(6):737-40. doi: 10.1016/0091-3057(79)90274-0.
The present study examines the dose-response pattern of delta 9-tetrahydrocannabinol self-injection in naive rats at 80% reduced body weight and 100% body weight, both conditions with a fixed-time 1 min (FT-1) food delivery schedule. The results indicated that food deprived animals tested on a FT-1 min schedule self-injected low doses of delta 9-THC at a higher rate than those animals at 100% body weight and on a FT-1 min schedule. Animals at 80% reduced body weight without a schedule did not differ from rats self-injecting delta 9-THC at free feeding situation. These findings suggest that rats without previous history of drug dependence self-administer low doses of delta 9-THC and that the interaction between the food deprivation state and the environmental contingencies introduced by a FT-1 min schedule is a critical variable in the acquisition period.
本研究考察了初用大鼠在体重减轻80%和体重正常这两种情况下，按固定时间1分钟（FT-1）食物供应时间表自行注射δ9-四氢大麻酚的剂量反应模式。结果表明，按FT-1分钟时间表接受测试的食物剥夺动物，自行注射低剂量δ9-四氢大麻酚的频率高于体重正常且按FT-1分钟时间表接受测试的动物。体重减轻80%且无时间表的动物与在自由进食情况下自行注射δ9-四氢大麻酚的大鼠没有差异。这些发现表明，无前药物依赖史的大鼠会自行服用低剂量δ9-四氢大麻酚，并且食物剥夺状态与FT-1分钟时间表引入的环境条件之间的相互作用是获取期的一个关键变量。
