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4-Aminopyridine suppresses positional nystagmus caused by cerebellar vermis lesion.

作者信息

Kremmyda O, Zwergal A, la Fougère C, Brandt T, Jahn K, Strupp M

出版信息

J Neurol. 2013 Jan;260(1):321-3. doi: 10.1007/s00415-012-6737-6. Epub 2012 Nov 24.

DOI:10.1007/s00415-012-6737-6

PMID:23180177

Abstract

摘要

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4-Aminopyridine suppresses positional nystagmus caused by cerebellar vermis lesion.

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4-aminopyridine improves downbeat nystagmus, smooth pursuit, and VOR gain.

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A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.

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Downbeat Nystagmus: Case Report, Updated Review, Therapeutics, and Neurorehabilitation.

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4-AP-3-MeOH Promotes Structural and Functional Spontaneous Recovery in the Acute Sciatic Nerve Stretch Injury.

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本文引用的文献

A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.

Neurology. 2011 Jul 19;77(3):269-75. doi: 10.1212/WNL.0b013e318225ab07. Epub 2011 Jul 6.

Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.

Neurology. 2003 Jul 22;61(2):165-70. doi: 10.1212/01.wnl.0000078893.41040.56.

Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus.

Ann Neurol. 2002 Dec;52(6):712-21. doi: 10.1002/ana.10370.

Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells.

Exp Brain Res. 2001 Aug;139(4):419-25. doi: 10.1007/s002210100788.

Diagnostic criteria for central versus peripheral positioning nystagmus and vertigo: a review.

Acta Otolaryngol. 1999 Jan;119(1):1-5. doi: 10.1080/00016489950181855.

Downbeating nystagmus. A review of 62 cases.

Arch Neurol. 1983 Dec;40(13):777-84. doi: 10.1001/archneur.40.13.777.

Positional vertigo and the cerebellar vermis.

Neurology. 1984 Apr;34(4):527-9. doi: 10.1212/wnl.34.4.527.

The mechanism of downbeat nystagmus.

Arch Neurol. 1974 Mar;30(3):227-37. doi: 10.1001/archneur.1974.00490330035006.

Afferent and efferent connections of the oculomotor cerebellar vermis in the macaque monkey.

J Comp Neurol. 1987 Nov 8;265(2):224-41. doi: 10.1002/cne.902650207.

Posterior vermal Purkinje cells in macaques responding during saccades, smooth pursuit, chair rotation and/or optokinetic stimulation.

Neurosci Res. 1992 Jan;12(5):583-95. doi: 10.1016/0168-0102(92)90065-k.

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相似文献

4-Aminopyridine suppresses positional nystagmus caused by cerebellar vermis lesion.

J Neurol. 2013 Jan;260(1):321-3. doi: 10.1007/s00415-012-6737-6. Epub 2012 Nov 24.

Beneficial effects of 3,4-diaminopyridine on positioning downbeat nystagmus in a circumscribed uvulo-nodular lesion.

J Neurol. 2007 Aug;254(8):1126-8. doi: 10.1007/s00415-006-0448-9. Epub 2007 Apr 6.

18F-fluorodeoxyglucose hypometabolism in cerebellar tonsil and flocculus in downbeat nystagmus.

Neuroreport. 2006 Apr 24;17(6):599-603. doi: 10.1097/00001756-200604240-00009.

Potassium channels, the cerebellum, and treatment for downbeat nystagmus.

Neurology. 2003 Jul 22;61(2):158-9. doi: 10.1212/wnl.61.2.158.

Update on the pharmacotherapy of cerebellar and central vestibular disorders.

J Neurol. 2016 Apr;263 Suppl 1:S24-9. doi: 10.1007/s00415-015-7987-x. Epub 2016 Apr 15.

4-aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus.

Brain. 2007 Sep;130(Pt 9):2441-51. doi: 10.1093/brain/awm172. Epub 2007 Jul 29.

4-aminopyridine improves downbeat nystagmus, smooth pursuit, and VOR gain.

Neurology. 2004 Apr 13;62(7):1228-9. doi: 10.1212/01.wnl.0000118287.68294.e5.

A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.

Neurology. 2011 Nov 29;77(22):1996-7; author reply 1997. doi: 10.1212/WNL.0b013e31823c162b.

Effects of 4-aminopyridine on nystagmus and vestibulo-ocular reflex in ataxia-telangiectasia.

J Neurol. 2013 Nov;260(11):2728-35. doi: 10.1007/s00415-013-7046-4. Epub 2013 Jul 25.

4-aminopyridine restores visual ocular motor function in upbeat nystagmus.

J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):451-3. doi: 10.1136/jnnp.2004.045716.

引用本文的文献

Downbeat Nystagmus: Case Report, Updated Review, Therapeutics, and Neurorehabilitation.

Brain Sci. 2025 Aug 13;15(8):859. doi: 10.3390/brainsci15080859.

4-AP-3-MeOH Promotes Structural and Functional Spontaneous Recovery in the Acute Sciatic Nerve Stretch Injury.

Dose Response. 2020 Jan 21;18(1):1559325819899254. doi: 10.1177/1559325819899254. eCollection 2020 Jan-Mar.

Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment.

Front Neurol. 2018 Feb 5;9:31. doi: 10.3389/fneur.2018.00031. eCollection 2018.

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J Neurol. 2018 Mar;265(3):714-716. doi: 10.1007/s00415-018-8775-1. Epub 2018 Feb 2.

[Vertigo and dizziness in the emergency room].

Nervenarzt. 2017 Jun;88(6):587-596. doi: 10.1007/s00115-017-0342-y.

Aminopyridines for the treatment of neurologic disorders.

Neurol Clin Pract. 2017 Feb;7(1):65-76. doi: 10.1212/CPJ.0000000000000321.

4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.

EMBO Mol Med. 2016 Dec 1;8(12):1409-1420. doi: 10.15252/emmm.201506035. Print 2016 Dec.

Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.

Cerebellum. 2016 Feb;15(1):38-42. doi: 10.1007/s12311-015-0733-1.

[Diagnosis and treatment options in vertigo syndromes].

Nervenarzt. 2015 Oct;86(10):1277-90. doi: 10.1007/s00115-015-4389-3.

Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.

Cerebellum. 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3.

本文引用的文献

A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.

Neurology. 2011 Jul 19;77(3):269-75. doi: 10.1212/WNL.0b013e318225ab07. Epub 2011 Jul 6.

Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.

Neurology. 2003 Jul 22;61(2):165-70. doi: 10.1212/01.wnl.0000078893.41040.56.

Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus.

Ann Neurol. 2002 Dec;52(6):712-21. doi: 10.1002/ana.10370.

Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells.

Exp Brain Res. 2001 Aug;139(4):419-25. doi: 10.1007/s002210100788.

Diagnostic criteria for central versus peripheral positioning nystagmus and vertigo: a review.

Acta Otolaryngol. 1999 Jan;119(1):1-5. doi: 10.1080/00016489950181855.

Downbeating nystagmus. A review of 62 cases.

Arch Neurol. 1983 Dec;40(13):777-84. doi: 10.1001/archneur.40.13.777.

Positional vertigo and the cerebellar vermis.

Neurology. 1984 Apr;34(4):527-9. doi: 10.1212/wnl.34.4.527.

The mechanism of downbeat nystagmus.

Arch Neurol. 1974 Mar;30(3):227-37. doi: 10.1001/archneur.1974.00490330035006.

Afferent and efferent connections of the oculomotor cerebellar vermis in the macaque monkey.

J Comp Neurol. 1987 Nov 8;265(2):224-41. doi: 10.1002/cne.902650207.

Posterior vermal Purkinje cells in macaques responding during saccades, smooth pursuit, chair rotation and/or optokinetic stimulation.

Neurosci Res. 1992 Jan;12(5):583-95. doi: 10.1016/0168-0102(92)90065-k.