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4-Aminopyridine suppresses positional nystagmus caused by cerebellar vermis lesion.

作者信息

Kremmyda O, Zwergal A, la Fougère C, Brandt T, Jahn K, Strupp M

出版信息

J Neurol. 2013 Jan;260(1):321-3. doi: 10.1007/s00415-012-6737-6. Epub 2012 Nov 24.

DOI:10.1007/s00415-012-6737-6
PMID:23180177
Abstract
摘要

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3
18F-fluorodeoxyglucose hypometabolism in cerebellar tonsil and flocculus in downbeat nystagmus.下跳性眼球震颤患者小脑扁桃体和绒球的18F-氟脱氧葡萄糖代谢减低
Neuroreport. 2006 Apr 24;17(6):599-603. doi: 10.1097/00001756-200604240-00009.
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Potassium channels, the cerebellum, and treatment for downbeat nystagmus.钾通道、小脑与下跳性眼球震颤的治疗
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J Neurol. 2016 Apr;263 Suppl 1:S24-9. doi: 10.1007/s00415-015-7987-x. Epub 2016 Apr 15.
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Neurology. 2004 Apr 13;62(7):1228-9. doi: 10.1212/01.wnl.0000118287.68294.e5.
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本文引用的文献

1
A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.EA2 及相关家族性发作性共济失调患者中 4-氨基吡啶的随机试验。
Neurology. 2011 Jul 19;77(3):269-75. doi: 10.1212/WNL.0b013e318225ab07. Epub 2011 Jul 6.
2
Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.3,4-二氨基吡啶治疗下跳性眼球震颤:一项安慰剂对照研究。
Neurology. 2003 Jul 22;61(2):165-70. doi: 10.1212/01.wnl.0000078893.41040.56.
3
Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus.
多发性硬化症中的眼球运动异常:发病机制、模型与治疗
Front Neurol. 2018 Feb 5;9:31. doi: 10.3389/fneur.2018.00031. eCollection 2018.
4
Downbeat nystagmus and lower motor neuron disease: 14 years follow-up.下跳性眼球震颤与下运动神经元疾病:14年随访
J Neurol. 2018 Mar;265(3):714-716. doi: 10.1007/s00415-018-8775-1. Epub 2018 Feb 2.
5
[Vertigo and dizziness in the emergency room].[急诊室中的眩晕与头晕]
Nervenarzt. 2017 Jun;88(6):587-596. doi: 10.1007/s00115-017-0342-y.
6
Aminopyridines for the treatment of neurologic disorders.用于治疗神经系统疾病的氨基吡啶类药物。
Neurol Clin Pract. 2017 Feb;7(1):65-76. doi: 10.1212/CPJ.0000000000000321.
7
4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.4-氨基吡啶可促进急性周围神经损伤后的功能恢复和髓鞘再生。
EMBO Mol Med. 2016 Dec 1;8(12):1409-1420. doi: 10.15252/emmm.201506035. Print 2016 Dec.
8
Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.小脑共济失调和眼球震颤的药物治疗进展
Cerebellum. 2016 Feb;15(1):38-42. doi: 10.1007/s12311-015-0733-1.
9
[Diagnosis and treatment options in vertigo syndromes].[眩晕综合征的诊断与治疗选择]
Nervenarzt. 2015 Oct;86(10):1277-90. doi: 10.1007/s00115-015-4389-3.
10
Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.共识文件:重新审视小脑综合征的症状和体征
Cerebellum. 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3.
小脑性下跳性眼球震颤患者眼漂移的重力依赖性
Ann Neurol. 2002 Dec;52(6):712-21. doi: 10.1002/ana.10370.
4
Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells.
Exp Brain Res. 2001 Aug;139(4):419-25. doi: 10.1007/s002210100788.
5
Diagnostic criteria for central versus peripheral positioning nystagmus and vertigo: a review.中枢性与周围性位置性眼球震颤和眩晕的诊断标准:综述
Acta Otolaryngol. 1999 Jan;119(1):1-5. doi: 10.1080/00016489950181855.
6
Downbeating nystagmus. A review of 62 cases.下跳性眼球震颤。62例病例回顾。
Arch Neurol. 1983 Dec;40(13):777-84. doi: 10.1001/archneur.40.13.777.
7
Positional vertigo and the cerebellar vermis.
Neurology. 1984 Apr;34(4):527-9. doi: 10.1212/wnl.34.4.527.
8
The mechanism of downbeat nystagmus.下跳性眼球震颤的机制。
Arch Neurol. 1974 Mar;30(3):227-37. doi: 10.1001/archneur.1974.00490330035006.
9
Afferent and efferent connections of the oculomotor cerebellar vermis in the macaque monkey.猕猴动眼神经小脑蚓部的传入和传出连接
J Comp Neurol. 1987 Nov 8;265(2):224-41. doi: 10.1002/cne.902650207.
10
Posterior vermal Purkinje cells in macaques responding during saccades, smooth pursuit, chair rotation and/or optokinetic stimulation.猕猴的小脑蚓部后叶浦肯野细胞在扫视、平稳跟踪、椅子旋转和/或视动刺激期间产生反应。
Neurosci Res. 1992 Jan;12(5):583-95. doi: 10.1016/0168-0102(92)90065-k.