Sport, Health and Exercise Science, Department for Health, University of Bath, Bath, United Kingdom.
Int J Sports Med. 2013 Apr;34(4):355-63. doi: 10.1055/s-0032-1311594. Epub 2012 Nov 23.
We compared 3 months of eucaloric (12 kcal/kg/wk) steady state aerobic training (AER) to interval training (INT) in men at risk for insulin resistance. Primary outcomes included oral glucose tolerance testing (OGTT) and HOMA-IR 24 h and 72 h after each participants last exercise session. Secondary outcomes were VO2max, anthropometry, and metabolic syndrome expressed as a summed z-score (zMS). We also performed a sub-analysis for participants entering the trial above and below the HOMA-IR study median. Mean (95% CI) AER ( - 12.81 mg/dl; - 24.7, - 1.0) and INT ( - 14.26 mg/dl; - 24.9, - 3.6) significantly improved 24 h OGTT. HOMA-IR did not improve for AER, but did for INT 24 h and 72 h post-exercise. VO2max improved similarly for both groups. Changes in body mass for INT ( - 2.29 kg; - 3.51, - 1.14), AER, ( - 1.32 kg; - 2.62, 0.58)] and percent body fat [INT, - 0.83%; - 1.62, - 0.03), AER ( - 0.17%; - 1.07, 0.06)] were only significant for INT. When examined as a full cohort, zMS improved for both groups. Upon HOMA-IR stratification, only high HOMA-IR AER showed significant improvements, while both low and high INT HOMA-IR participants demonstrated significant reductions (P<0.05). Eucaloric AER and INT appear to affect fasting glucose, OGTT and VO2max similarly, while INT may have a greater impact on HOMA-IR and zMS.
我们比较了 3 个月的热量平衡（12 kcal/kg/wk）稳定状态有氧运动（AER）和间歇训练（INT）对胰岛素抵抗风险男性的影响。主要结局包括口服葡萄糖耐量试验（OGTT）和参与者最后一次运动后 24 小时和 72 小时的 HOMA-IR。次要结局为 VO2max、人体测量学和代谢综合征表示为总和 z 分数（zMS）。我们还对进入试验的参与者进行了 HOMA-IR 研究中位数以上和以下的亚分析。AER（-12.81mg/dl；-24.7，-1.0）和 INT（-14.26mg/dl；-24.9，-3.6）的平均值（95%CI）显著改善 24 小时 OGTT。AER 组的 HOMA-IR 没有改善，但 INT 组在运动后 24 小时和 72 小时改善。两组的 VO2max 改善相似。INT（-2.29kg；-3.51，-1.14）和 AER（-1.32kg；-2.62，0.58）的体重变化和体脂百分比[INT，-0.83%；-1.62，-0.03），AER（-0.17%；-1.07，0.06）]仅对 INT 有意义。当作为一个完整的队列进行检查时，两组的 zMS 都有所改善。在 HOMA-IR 分层后，只有高 HOMA-IR AER 显示出显著改善，而低和高 HOMA-IR INT 参与者均显示出显著降低（P<0.05）。热量平衡的 AER 和 INT 似乎对空腹血糖、OGTT 和 VO2max 有相似的影响，而 INT 可能对 HOMA-IR 和 zMS 有更大的影响。
