Nasiri Masoud, Monazzami Amirabbas, Alavimilani Solmaz, Asemi Zatollah
Department of Sport Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Department of Obstetrics and Gynecology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Endocr Disord. 2025 Jan 2;25(1):1. doi: 10.1186/s12902-024-01793-0.
Polycystic ovary syndrome (PCOS) is a frequent disorder among women. Exercise training has been known as an effective treatment for this disorder; however, there is small amount of evidence examining the optimal exercise programs. We evaluated the function of combined (COM) training on metabolic, hormonal parameters, and biomarkers of oxidative stress and inflammation in PCOS patients.
This randomized controlled clinical trial was conducted on 30 women with PCOS divided (age: 23.8 ± 5.3 years, height:162.8 ± 4.9 cm, weight: 82.4 ± 9.7 kg, body mass index: 30.3 ± 3.9 kg/m) into two groups to receive COM training intervention (n = 15) or control group (n = 15) for eight weeks. At the baseline and end-of-intervention, metabolic profiles including fasting plasma glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), lipid profiles, testosterone, free androgen index (FAI), sex hormone binding globulin, anti-Müllerian hormone, malondialdehyde, total antioxidant capacity, and high Sensitive-C reactive protein were evaluated.
After eight-week intervention in training group, insulin (P < 0.001), HOMA-IR (P < 0.001), total cholesterol (P < 0.001), LDL-cholesterol (P < 0.001), total testosterone (P < 0.001), AMH ( P = 0.02),MDA (P = 0.04) and FAI (P < 0.001) were significantly decreased, while QUICKI (P = 0.002) was remarkably increased compared with the control group. Moreover, findings showed that there are no significant differences in other variables in the training group compared to the control group.
We concluded that combined training is an effective training protocol (50%-70% 1RM for strength training and 60%-70 THR for endurance training) for treatment of PCOS, although further studies are needed to reach comprehensive data regarding the design of exercise protocols with different intensity and volume for PCOS patients.
Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20130812014333N143) on March 22, 2020. Access at https://en.irct.ir/trial/46295 .
多囊卵巢综合征（PCOS）是女性中的常见病症。运动训练已知是治疗该病症的有效方法；然而，检验最佳运动方案的证据较少。我们评估了联合（COM）训练对PCOS患者代谢、激素参数以及氧化应激和炎症生物标志物的作用。
这项随机对照临床试验对30名PCOS女性进行（年龄：23.8±5.3岁，身高：162.8±4.9厘米，体重：82.4±9.7千克，体重指数：30.3±3.9千克/平方米），分为两组，接受COM训练干预（n = 15）或对照组（n = 15），为期八周。在基线和干预结束时，评估代谢指标，包括空腹血糖、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、定量胰岛素敏感性检查指数（QUICKI）、血脂谱、睾酮、游离雄激素指数（FAI）、性激素结合球蛋白、抗苗勒管激素、丙二醛、总抗氧化能力和高敏C反应蛋白。
训练组经过八周干预后，与对照组相比，胰岛素（P < 0.001）、HOMA-IR（P < 0.001）、总胆固醇（P < 0.001）、低密度脂蛋白胆固醇（P < 0.001）、总睾酮（P < 0.001）、抗苗勒管激素（P = 0.02）、丙二醛（P = 0.04）和FAI（P < 0.001）显著降低，而QUICKI（P = 0.002）显著升高。此外，结果显示训练组与对照组相比，其他变量无显著差异。
我们得出结论，联合训练是治疗PCOS的有效训练方案（力量训练为1RM的50%-70%，耐力训练为60%-70%心率储备），尽管需要进一步研究以获得关于针对PCOS患者设计不同强度和运动量运动方案的全面数据。
于2020年3月22日在伊朗临床试验注册中心（IRCT20130812014333N143）进行回顾性注册。可在https://en.irct.ir/trial/46295查阅。
