Garg Sunny, Mishra Sourav, Tondon Ravi, Tripathi Kamlakar
Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Int J Trichology. 2012 Jul;4(3):169-71. doi: 10.4103/0974-7753.100085.
Alopecia is a rare manifestation of Hodgkin's disease. It may be due to follicular destruction due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. In this patient, hair loss, diffuse yperpigmentation, and generalized itching preceded other manifestations of the disease. The pattern of hair loss was diffuse and generalized in nature involving scalp, eyebrows, axilla, and groin. Subsequently, the patient was diagnosed to be a case of Hodgkin's lymphoma, based on clinical and histopathological features. Earlier reports on alopecia accompanying Hodgkin's disease have also been discussed. This case highlights the importance of keeping a high suspicion of an underlying malignancy in patients presenting with such cutaneous manifestations.
脱发是霍奇金病的一种罕见表现。它可能是由于疾病直接浸润导致毛囊破坏，也可能是一种继发性或副肿瘤性表现。在该患者中，脱发、弥漫性色素沉着和全身瘙痒先于疾病的其他表现出现。脱发模式为弥漫性和全身性，累及头皮、眉毛、腋窝和腹股沟。随后，根据临床和组织病理学特征，该患者被诊断为霍奇金淋巴瘤。文中还讨论了先前关于霍奇金病伴发脱发的报道。该病例强调了对出现此类皮肤表现的患者高度怀疑潜在恶性肿瘤的重要性。
