Gong Jun, Lim Stephen W
Department of Internal Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Blood and Marrow Transplant Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Mol Clin Oncol. 2014 Jul;2(4):596-598. doi: 10.3892/mco.2014.274. Epub 2014 Apr 9.
Alopecia areata (AA) has been classically associated with several autoimmune disorders. However, AA as a paraneoplastic syndrome of Hodgkin's lymphoma (HL) remains a rare entity and our understanding of this phenomenon is limited to a few case reports. This is the case report of a 46-year-old male patient who was diagnosed with AA several months prior to the onset of B symptoms and the diagnosis of stage IVB classical HL. The patient was subsequently treated with 6 cycles of adriamycin, bleomycin, vinblastine and dacarbazine and experienced a complete response and resolution of his AA. In our case, the onset of AA preceded the onset of systemic manifestations and diagnosis of HL, whereas in other cases AA was shown to occur concurrently with the clinical manifestations of HL. In all the cases, however, treatment of the HL subsequently led to resolution of the AA. The present case report highlights the significance of AA as a herald of underlying malignancy, although AA in classical HL remains poorly characterized in the literature.
斑秃（AA）一直以来都与多种自身免疫性疾病存在经典关联。然而，AA作为霍奇金淋巴瘤（HL）的副肿瘤综合征仍然是一种罕见情况，我们对这一现象的了解仅限于少数病例报告。本文报告了一名46岁男性患者，他在出现B症状及诊断为IVB期经典型HL的数月前被诊断出患有AA。该患者随后接受了6个周期的阿霉素、博来霉素、长春花碱和达卡巴嗪治疗，AA完全缓解。在我们的病例中，AA的出现先于HL的全身表现和诊断，而在其他病例中，AA与HL的临床表现同时出现。然而，在所有病例中，HL的治疗随后都导致了AA的缓解。本病例报告强调了AA作为潜在恶性肿瘤先兆的重要性，尽管经典型HL中的AA在文献中仍缺乏充分描述。
