DNGM Research Foundation, 37/C, Block 'B', New Alipore, Kolkata 700053, India.
Public Health Nutr. 2013 Sep;16(9):1644-55. doi: 10.1017/S1368980012004697. Epub 2012 Nov 27.
To assess whether nutritional deficiency increases susceptibility to arsenic-related health effects.
Assessment of nutrition was based on a 24 h recall method of all dietary constituents.
Epidemiological cross-sectional study was conducted in an arsenic endemic area of West Bengal with groundwater arsenic contamination.
The study was composed of two groups – Group 1 (cases, n 108) exhibiting skin lesions and Group 2 (exposed controls, n 100) not exhibiting skin lesions – age- and sex-matched and having similar arsenic exposure through drinking water and arsenic levels in urine and hair.
Both groups belonged to low socio-economic strata (Group 1 significantly poorer, P<0·01) and had low BMI (prevalence of BMI<18·5 kg/m2: in 38% in Group 1 and 27% in Group 2). Energy intake was below the Recommended Daily Allowance (set by the Indian Council of Medical Research) in males and females in both groups. Increased risk of arsenical skin lesions was found for those in the lowest quintile of protein intake (v. highest quintile: OR=4·60, 95% CI 1·36, 15·50 in males; OR=5·62, 95% CI 1·19, 34·57 in females). Significantly lower intakes of energy, protein, thiamin, niacin, Mg, Zn and choline were observed in both males and females of Group 1 compared with Group 2. Significantly lower intakes of carbohydrate, riboflavin, niacin and Cu were also observed in female cases with skin lesions compared with non-cases.
Deficiencies of Zn, Mg and Cu, in addition to protein, B vitamins and choline, are found to be associated with arsenical skin lesions in West Bengal.
评估营养缺乏是否会增加砷相关健康影响的易感性。
营养评估基于所有膳食成分的 24 小时回忆法。
在孟加拉国一个地下水砷污染的砷流行地区进行了一项流行病学横断面研究。
该研究由两组组成——表现出皮肤损伤的第 1 组（病例，n=108）和未表现出皮肤损伤的第 2 组（暴露对照组，n=100）——年龄和性别匹配，通过饮用水和尿液和头发中的砷水平有相似的砷暴露。
两组都属于低社会经济阶层（第 1 组明显更穷，P<0·01），且 BMI 较低（BMI<18·5 kg/m2的患病率：第 1 组为 38%，第 2 组为 27%）。两组男性和女性的能量摄入量均低于印度医学研究理事会设定的每日推荐摄入量。发现摄入最低五分位的蛋白质与摄入最高五分位的蛋白质相比，患砷性皮肤损伤的风险增加（男性：最低五分位组的 OR=4·60，95%CI 1·36，15·50；女性：最低五分位组的 OR=5·62，95%CI 1·19，34·57）。与第 2 组相比，第 1 组的男性和女性均观察到能量、蛋白质、硫胺素、烟酸、Mg、Zn 和胆碱的摄入量显著降低。与非病例相比，患有皮肤损伤的女性病例还观察到碳水化合物、核黄素、烟酸和 Cu 的摄入量显著降低。
除了蛋白质、B 族维生素和胆碱外，还发现 Zn、Mg 和 Cu 的缺乏与孟加拉国的砷性皮肤损伤有关。
