《2021年全球疾病负担研究分析：1990年至2021年全球、区域和国家营养缺乏负担》

Analysis of study Global Burden of Disease in 2021: global, regional, and national burden of nutritional deficiency from 1990 to 2021.

作者信息

Chen Jing, Li Zedong, Liu Hong

机构信息

Department of Surgery, Institute of Integrated Traditional Chinese and Western Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Front Nutr. 2025 Jan 15;11:1540485. doi: 10.3389/fnut.2024.1540485. eCollection 2024.

BACKGROUND

Nutrient deficiency disorders (NDs) harm growth, causing economic losses. Addressing NDs is a global priority, yet recent data is limited. This study examines latest NDs data across 204 countries and 21 regions from 1990 to 2021.

METHODS

Data from the 2021 Global Burden of Disease (GBD) study were used to analyze NDs-related incidence, prevalence, deaths, and disability-adjusted life years (DALYs) at global, national, and regional levels. Joinpoint regression analysis was applied to evaluate temporal trends, with Estimated Annual Percentage Change (EAPC) assessing long-term patterns.

RESULTS

In 2021, the global burden of NDs remained substantial, with a total of 1,845,246,558 cases with an ASPR of 23,858.99 cases per 100,000 individuals (95% UI: 23,445.77-24,320.82). The ASIR was 7,725.1 per 100,000 people (95% UI: 7,404.01-8,109.01), while the ASMR was 3.03 per 100,000 persons (95% UI: 2.69-3.4). Additionally, age-standardized DALYs rate was 657.62 per 100,000 individuals (95% UI: 489.93-869.58). Regionally, areas with low SDI exhibited the greatest ASPR, ASIR, ASDR, and age-standardized DALYs rates, whereas high SDI regions had the lowest rates.

CONCLUSIONS

Although global NDs burden has declined from 1990 to 2021, regional and demographic disparities remain. Enhanced healthcare access in high-risk SDI regions is essential to further mitigate NDs's global impact.

背景

营养缺乏症（NDs）危害生长发育，造成经济损失。解决营养缺乏症是全球优先事项，但近期数据有限。本研究调查了1990年至2021年期间204个国家和21个地区的最新营养缺乏症数据。

方法

使用2021年全球疾病负担（GBD）研究的数据，在全球、国家和地区层面分析与营养缺乏症相关的发病率、患病率、死亡率和伤残调整生命年（DALYs）。采用Joinpoint回归分析评估时间趋势，用估计年度百分比变化（EAPC）评估长期模式。

结果

2021年，全球营养缺乏症负担依然沉重，共有1,845,246,558例病例，每10万人的年龄标准化患病率（ASPR）为23,858.99例（95%不确定区间：23,445.77 - 24,320.82）。每10万人的年龄标准化发病率（ASIR）为7,725.1例（95%不确定区间：7,404.01 - 8,109.01），每10万人的年龄标准化死亡率（ASMR）为3.03例（95%不确定区间：2.69 - 3.4）。此外，每10万人的年龄标准化伤残调整生命年率为657.62（95%不确定区间：489.93 - 869.58）。在区域层面，社会人口指数（SDI）较低的地区ASPR、ASIR、年龄标准化死亡率（ASDR）和年龄标准化伤残调整生命年率最高，而SDI较高的地区这些比率最低。