神经酰胺应激在存活与致命自噬悖论中的作用：神经酰胺将自噬体靶向线粒体并诱导致命的线粒体自噬。
Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
机构信息
Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Charleston, SC, USA.
出版信息
Autophagy. 2013 Feb 1;9(2):258-9. doi: 10.4161/auto.22739. Epub 2012 Nov 26.
Abstract
In a recent study, characterization of novel mechanisms that regulate lethal autophagy revealed that C 18-ceramide stress mediates LC3B-II-ceramide binding on mitochondrial membranes to target autophagosomes for mitophagy induction and tumor suppression.
摘要
在最近的一项研究中，对调节致命自噬的新机制进行了特征描述，结果表明 C18-神经酰胺应激介导 LC3B-II-神经酰胺与线粒体膜结合，将自噬体作为靶向自噬诱导和肿瘤抑制的目标。
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