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类风湿关节炎中的循环免疫复合物。一项个人研究的结果(作者译)

[Circulating immune complexes in rheumatoid arthritis. Results of a personal research (author's transl)].

作者信息

Kuntz J L, Pasquali J L, Thierry R, Meyer R, Vautravers P, Asch L

出版信息

Sem Hop. 1979;55(35-36):1597-600.

PMID:231829
Abstract

Using the technic of Pillot and Grangeot (précipitation by PEG 6,000 at 2.5%, followed radial immuno-diffusion), the authors have detected circulating immune complexes (CIC) 38 times in a group of 55 RA. The presence of CIC is significantly more frequent in sero-positive RA, but without correlation between the concentration of CIC and the positivity rate of Waaler-Rose reaction. There is no correlation between the evolutive state of RA and the presence or the concentration of CIC. The sedimentation rate is, in mean, significantly higher in RA with CIC; but, among these, there is no correlation between sedimentation rate and the concentration of CIC. In the group studied, the CIC are present in all cases of RA with vasculitis or visceral symptoms.

摘要

作者采用皮洛特和格兰乔技术(用2.5%的聚乙二醇6000沉淀,随后进行放射免疫扩散),在一组55例类风湿关节炎(RA)患者中检测到循环免疫复合物(CIC)38次。血清阳性的类风湿关节炎患者中CIC的存在明显更为常见,但CIC浓度与瓦勒-罗斯反应阳性率之间无相关性。类风湿关节炎的病情发展状态与CIC的存在或浓度之间无相关性。平均而言,有CIC的类风湿关节炎患者的血沉明显更高;但在这些患者中,血沉与CIC浓度之间无相关性。在所研究的组中,血管炎或内脏症状的所有类风湿关节炎病例均存在CIC。

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