Duquesnoy B, Asfour M, Santoro F, Vandemeulebroucke B, Hochart J P, Delcambre B
Rev Rhum Mal Osteoartic. 1980 Jul-Sep;47(7-9):481-7.
In this work, the authors found significantly raised serum Beta2m microglobulin values in a group of 120 cases of rheumatoid arthritis, without any difference between the serum positive group (55 cases) and the serum negative group (65 cases). Such a rise was found in the synovial fluids with a beta2 serum synovial fluid greater than unity in 81 % of cases of rheumatoid arthritis as against 6 % in a control group. The comparative study and the main immunological disorders permits one to note a correlation between the levels of circulating immune complexes (CIC) fixing the Clq and the serum beta2m in serum negative cases of rheumatoid arthritis (RA) (r = 0.52 p < 0.001) whereas this link does not exist in the serum positive group (r = 0.08). These conclusions led the authors to an anti-serum beta2m activity in the serum positive and negative groups of RA, which were very significantly different from the control groups. Furthermore, a study of complement activation, by titration of C3d showed a significant correlation between the levels of CIC and of C3d in RA -, but not in RA +. The authors discuss the participation of beta2m in the formatiton of CIC during RA and its role in the activation of complement.
在这项研究中，作者发现120例类风湿关节炎患者的血清β2微球蛋白值显著升高，血清阳性组（55例）和血清阴性组（65例）之间无差异。在类风湿关节炎患者的滑膜液中发现了这种升高，81%的类风湿关节炎病例滑膜液β2/血清β2大于1，而对照组为6%。通过比较研究和主要免疫紊乱情况，发现类风湿关节炎血清阴性病例中循环免疫复合物（CIC）结合Clq的水平与血清β2微球蛋白之间存在相关性（r = 0.52，p < 0.001），而血清阳性组不存在这种联系（r = 0.08）。这些结论使作者发现类风湿关节炎血清阳性和阴性组中抗血清β2微球蛋白活性与对照组有非常显著差异。此外，通过滴定C3d对补体激活的研究表明，类风湿关节炎血清阴性组中CIC水平与C3d水平之间存在显著相关性，而血清阳性组则不存在。作者讨论了β2微球蛋白在类风湿关节炎期间CIC形成中的作用及其在补体激活中的作用。
