天然（-）-秋水仙碱及别同系物的aS,7S-绝对构型。
aS,7S-absolute configuration of natural (-)-colchicine and allo-congeners.
作者信息
Brossi A, Boyé O, Muzaffar A, Yeh H J, Toome V, Wegrzynski B, George C
机构信息
Natural Products Section, NIDDK, National Institutes of Health, Bethesda, MD 20892.
出版信息
FEBS Lett. 1990 Mar 12;262(1):5-7. doi: 10.1016/0014-5793(90)80139-a.
PMID:2318312
Abstract
The aS,7S-absolute configuration of (-)-colchicine (1) and (-)-N-acetylcolchinol methyl ether (3, NCME) suggested on the basis of 1H NMR data and negative Cotton effects at about 260 nm (EtOH) is firmly established by an X-ray analysis of urea 5, a compound derived from 3. Binding of these compounds to tubulin requires an aS-configuration of the biaryl system.
摘要
基于1H NMR数据和在约260 nm（乙醇）处的负科顿效应所推测的(-)-秋水仙碱（1）和(-)-N-乙酰秋水仙醇甲醚（3，NCME）的aS,7S-绝对构型，通过对由3衍生而来的化合物脲5进行X射线分析得到了确证。这些化合物与微管蛋白的结合需要联芳基系统具有aS-构型。
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