Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Mansfield Road , Oxford OX1 3TA , U.K.
J Nat Prod. 2019 Sep 27;82(9):2659-2663. doi: 10.1021/acs.jnatprod.9b00595. Epub 2019 Sep 5.
The reported characterization data for the allocolchicinoid alkaloid suhailamine, isolated from and known to have an erroneous structure, have been reanalyzed. This analysis has led to the current proposal that suhailamine has the same structure as -acetylcolchinol methyl ether (NCME), an assertion that is supported by comparison with previously reported data for NCME. Suhailamine is therefore a phantom natural product, while NCME represents a naturally occurring allocolchicinoid rather than a purely synthetic entity.
对从 中分离出来的、已知结构错误的他克林生物碱的报道的特征化数据进行了重新分析。这一分析导致了目前的建议，即他克林胺具有与 -乙酰基秋水仙碱甲基醚（NCME）相同的结构，这一断言得到了与之前报道的 NCME 数据的比较的支持。因此，他克林胺是一种虚幻的天然产物，而 NCME 代表了一种天然存在的他克林生物碱，而不是纯粹的合成实体。
