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鉴定层粘连蛋白A链中的精氨酸-甘氨酸-天冬氨酸序列为在片段P1中暴露的潜在细胞结合位点。

Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1.

作者信息

Aumailley M, Gerl M, Sonnenberg A, Deutzmann R, Timpl R

机构信息

Max-Planck-Institut für Biochemie, Martinsried, FRG.

出版信息

FEBS Lett. 1990 Mar 12;262(1):82-6. doi: 10.1016/0014-5793(90)80159-g.

DOI:10.1016/0014-5793(90)80159-g
PMID:2318314
Abstract

A single RGD-containing sequence present within an epidermal growth factor-like repeat of the short arms of laminin is shown by peptide inhibition to block integrin receptors recognizing a latent cell-binding site of laminin. Based on proteolysis data it is proposed that masking occurs by folding of the globular domain IVa over the cell-binding site in the adjacent rod-like structures of laminin A chain.

摘要

层粘连蛋白短臂的表皮生长因子样重复序列中存在的单个含RGD序列，经肽抑制实验表明可阻断整合素受体识别层粘连蛋白潜在细胞结合位点。基于蛋白水解数据，推测掩盖作用是通过层粘连蛋白A链相邻杆状结构中球状结构域IVa折叠覆盖在细胞结合位点上而发生的。

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Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1.鉴定层粘连蛋白A链中的精氨酸-甘氨酸-天冬氨酸序列为在片段P1中暴露的潜在细胞结合位点。
FEBS Lett. 1990 Mar 12;262(1):82-6. doi: 10.1016/0014-5793(90)80159-g.
2
Structural and functional analysis of the globular domain IVa of the laminin alpha 1 chain and its impact on an adjacent RGD site.层粘连蛋白α1链球状结构域IVa的结构与功能分析及其对相邻RGD位点的影响
Biochem J. 1996 Mar 15;314 ( Pt 3)(Pt 3):847-51. doi: 10.1042/bj3140847.
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Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.整合素对层粘连蛋白不同细胞结合片段（P1、E3、E8）的识别以及α6β1而非α6β4作为片段E8主要受体发挥作用的证据。
J Cell Biol. 1990 Jun;110(6):2145-55. doi: 10.1083/jcb.110.6.2145.
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Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp.层粘连蛋白α5链的IVa结构域具有细胞黏附性，并通过精氨酸-甘氨酸-天冬氨酸序列与β1和αVβ3整合素结合。
FEBS Lett. 2001 Dec 7;509(2):181-5. doi: 10.1016/s0014-5793(01)03167-2.
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Binding of purified collagen receptors (alpha 1 beta 1, alpha 2 beta 1) and RGD-dependent integrins to laminins and laminin fragments.纯化的胶原蛋白受体（α1β1、α2β1）和RGD依赖性整合素与层粘连蛋白及层粘连蛋白片段的结合。
Eur J Biochem. 1994 Nov 1;225(3):975-84. doi: 10.1111/j.1432-1033.1994.0975b.x.
6
Multiple cell surface receptors for the short arms of laminin: alpha 1 beta 1 integrin and RGD-dependent proteins mediate cell attachment only to domains III in murine tumor laminin.层粘连蛋白短臂的多种细胞表面受体：α1β1整合素和RGD依赖性蛋白仅介导细胞与鼠肿瘤层粘连蛋白中结构域III的附着。
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7
Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.精氨酸-甘氨酸-天冬氨酸被限制在环五肽内。对细胞黏附于玻连蛋白和层粘连蛋白片段P1具有强效和选择性的抑制剂。
FEBS Lett. 1991 Oct 7;291(1):50-4. doi: 10.1016/0014-5793(91)81101-d.
8
Cell adhesion, spreading and neurite stimulation by laminin fragment E8 depends on maintenance of secondary and tertiary structure in its rod and globular domain.层粘连蛋白片段E8介导的细胞黏附、铺展及神经突刺激作用依赖于其杆状和球状结构域二级和三级结构的维持。
Eur J Biochem. 1990 Jul 31;191(2):513-22. doi: 10.1111/j.1432-1033.1990.tb19151.x.
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Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.整合素VLA-3的受体功能：纤连蛋白、胶原蛋白和层粘连蛋白的结合受到精氨酸-甘氨酸-天冬氨酸肽和二价阳离子的不同影响。
J Cell Biol. 1991 Jan;112(1):169-81. doi: 10.1083/jcb.112.1.169.
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Characterization of proteolytic fragments of the laminin-nidogen complex and their activity in ligand-binding assays.层粘连蛋白-巢蛋白复合物蛋白水解片段的表征及其在配体结合试验中的活性
Eur J Biochem. 1988 Dec 1;178(1):71-80. doi: 10.1111/j.1432-1033.1988.tb14430.x.

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