Bosch T C, David C N
Zoologisches Institut der Universität, Munich, Federal Republic of Germany.
Dev Biol. 1990 Apr;138(2):513-5. doi: 10.1016/0012-1606(90)90217-7.
The migration of interstitial cells was analyzed during the growth of stem cell clones in vivo. The spatial distribution of cloned cells was analyzed at a time by which extensive migration of interstitial cells could have occurred. All interstitial cell clones were found to form large contiguous patches of cells. The results indicate that there is little migration of large interstitial cells in undisturbed tissue during normal growth. This finding is surprising since numerous grafting experiments have shown extensive migration of these cells. The implications of finding nonrandomly distributed stem cells are discussed.
在体内干细胞克隆生长过程中分析了间质细胞的迁移情况。在间质细胞可能已经发生广泛迁移的时间点分析了克隆细胞的空间分布。发现所有间质细胞克隆都形成了大片连续的细胞斑块。结果表明，在正常生长过程中，未受干扰的组织中大型间质细胞的迁移很少。这一发现令人惊讶，因为大量移植实验已表明这些细胞会发生广泛迁移。本文讨论了发现非随机分布干细胞的意义。
