Marth C, Madersbacher S, Herold M, Berger P, Hetzel H, Fuith L C, Daxenbichler G
Universitätsklinik für Frauenheilkunde, Osterreichischen Akademie der Wissenschaften, Innsbruck.
Geburtshilfe Frauenheilkd. 1990 Feb;50(2):122-3. doi: 10.1055/s-2007-1026448.
The tumour necrosis factor (TNF) stimulates in cultured JAR choriocarcinoma cells the biosynthesis of hCG, including the free alpha and beta chain and the holo-hCG. Although elevated serum TNF levels have been shown by Balkwill et al. (1987) in about 50% of tumour patients, we were unable to confirm these data in the 10 examined patients, who had a choriocarcinoma. Despite its excellent in-vitro action, INF could not be confirmed to exercise an influence on the regulation of hCG in choriocarcinoma patients.
肿瘤坏死因子（TNF）可刺激培养的JAR绒毛膜癌细胞合成hCG，包括游离的α链和β链以及完整的hCG。尽管Balkwill等人（1987年）已表明约50%的肿瘤患者血清TNF水平升高，但我们无法在10例患有绒毛膜癌的受试患者中证实这些数据。尽管TNF在体外具有良好的作用，但无法证实在绒毛膜癌患者中它对hCG的调节有影响。
