胃泌素对大鼠部分肝切除术后肝脏再生的影响。
Effect of gastrin on liver regeneration after partial hepatectomy in rats.
作者信息
Rasmussen T N, Jørgensen P E, Almdal T, Poulsen S S, Olsen P S
机构信息
Department of Surgery C, Rigshospitalet, Copenhagen N, Denmark.
出版信息
Gut. 1990 Jan;31(1):92-5. doi: 10.1136/gut.31.1.92.
Gastrin has been shown to be an important trophic hormone for the mucosa of the stomach and the proximal intestine. In the present study the effect of gastrin on liver regeneration after partial hepatectomy in rats was investigated. After partial hepatectomy a significant rise in the concentration of gastrin in portal venous blood was found six, 12, and 18 hours after 70% hepatectomy. The effect of changes in the endogenous gastrin concentration on the liver regeneration was investigated in rats subjected to antrectomy or to fundectomy. Partial hepatectomy was done three weeks after the primary surgery. We found antrectomy to decrease liver regeneration, whereas fundectomy had no effect. Administration of pentagastrin 300 micrograms/kg sc three times daily for two and four days after partial hepatectomy significantly increased the rate of liver regeneration compared with controls. This study suggests that gastrin has a hepatotrophic effect. Whether this effect is caused by a direct action of gastrin on the hepatocytes or it is an indirect effect mediated by for instance insulin, glucagon or epidermal growth factor has to be further investigated.
胃泌素已被证明是一种对胃和近端肠道黏膜起重要营养作用的激素。在本研究中，对胃泌素在大鼠部分肝切除术后肝脏再生中的作用进行了研究。在70%肝切除术后6小时、12小时和18小时，发现部分肝切除术后门静脉血中胃泌素浓度显著升高。在接受胃窦切除术或胃底切除术的大鼠中，研究了内源性胃泌素浓度变化对肝脏再生的影响。在初次手术后三周进行部分肝切除术。我们发现胃窦切除术会降低肝脏再生，而胃底切除术则无影响。与对照组相比，在部分肝切除术后每天三次皮下注射300微克/千克的五肽胃泌素，持续两天和四天，显著提高了肝脏再生率。本研究表明胃泌素具有肝营养作用。这种作用是由胃泌素对肝细胞的直接作用引起的，还是由例如胰岛素、胰高血糖素或表皮生长因子介导的间接作用引起的，还有待进一步研究。
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