National Center for NanoScience and Technology, Beijing, China.
Adv Healthc Mater. 2013 Jan;2(1):95-108. doi: 10.1002/adhm.201200104. Epub 2012 Sep 13.
The adhesion of cells on an extracellular matrix (ECM) (in vivo) or the surfaces of materials (in vitro) is a prerequisite for most cells to survive. The rapid growth of nano/microfabrication and biomaterial technologies has provided new materials with excellent surfaces with specific, desirable biological interactions with their surroundings. On one hand, the chemical and physical properties of material surfaces exert an extensive influence on cell adhesion, proliferation, migration, and differentiation. On the other hand, material surfaces are useful for fundamental cell biology research and tissue engineering. In this Review, an overview will be given of the chemical and physical properties of newly developed material surfaces and their biological effects, as well as soft lithographic techniques and their applications in cell biology research. Recent advances in the manipulation of cell adhesion by the combination of surface chemistry and soft lithography will also be highlighted.
细胞在细胞外基质（ECM）（体内）或材料表面（体外）上的黏附是大多数细胞存活的前提条件。纳米/微加工和生物材料技术的快速发展为具有特定理想生物相互作用的周围环境的具有优异表面的新材料提供了条件。一方面，材料表面的化学和物理性质对细胞的黏附、增殖、迁移和分化有广泛的影响。另一方面，材料表面可用于基础细胞生物学研究和组织工程。在这篇综述中，将概述新开发的材料表面的化学和物理性质及其生物学效应，以及软光刻技术及其在细胞生物学研究中的应用。还将重点介绍通过表面化学和软光刻相结合来操纵细胞黏附的最新进展。
