Li Wen, Wang Jiasi, Ren Jinsong, Qu Xiaogang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization , Changchun Institute of Applied Chemistry , Chinese Academy of Sciences , Changchun , Jilin 130022 , P. R. China . Email:
University of Chinese Academy of Sciences , Beijing , 100039 , P. R. China.
Chem Sci. 2015 Dec 1;6(12):6762-6768. doi: 10.1039/c5sc02565f. Epub 2015 Aug 27.
Design of biological signal-responsive biomaterials is essential for controlling cell-cell and cell-matrix interactions. Herein, we developed a dynamic hydrogel to control cell adhesion with biological signals in a cellular microenvironment. The basic principle was based on using nucleic acid aptamer to recognize cell signalling and control the display of bioligands on the hydrogel. Not only exogenous signalling but also endogenous signalling secreted by surrounding cells could activate the dynamic scaffold and tune the cell adhesion state. Since diverse aptamers have been developed, our design can be extended to multiple biological inputs. The biochemical signal-responsive system will greatly enhance the understanding of complex biological processes as well as the ability to manipulate cellular behaviors.
生物信号响应性生物材料的设计对于控制细胞间和细胞与基质的相互作用至关重要。在此，我们开发了一种动态水凝胶，用于在细胞微环境中通过生物信号控制细胞黏附。其基本原理是利用核酸适配体识别细胞信号并控制水凝胶上生物配体的展示。不仅外源信号，而且周围细胞分泌的内源信号都可以激活动态支架并调节细胞黏附状态。由于已经开发出多种适配体，我们的设计可以扩展到多种生物输入。这种生化信号响应系统将极大地增进对复杂生物过程的理解以及操纵细胞行为的能力。
