Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Adv Healthc Mater. 2012 May;1(3):337-41. doi: 10.1002/adhm.201200033. Epub 2012 Apr 2.
Low molecular weight polyethyleneimines were conjugated onto gold nanoparticles to form Au-PEI conjugates. Au-PEI is the first reported gene carrier which has both high transfection efficiency and strong fluorescence. Au-PEI showed higher transfection efficiency and it can be used for bioimaging because it can be detected by confocal laser scanning microscopy and in vivo bioimaging system.
低分子量聚乙烯亚胺被共轭到金纳米粒子上形成 Au-PEI 缀合物。Au-PEI 是第一个报道的具有高转染效率和强荧光的基因载体。Au-PEI 表现出更高的转染效率，并且可以用于生物成像，因为它可以通过共焦激光扫描显微镜和体内生物成像系统进行检测。
