Du J W, Xu K Y, Fang L Y, Qi X L
School of Medicine, Anhui University of Science & Technology, Huainan, Anhui Province, PR China.
Eur J Gynaecol Oncol. 2012;33(5):455-8.
The aim of this study was to determine the expression patterns of Mena and Her-2 in breast cancer tissues and to explore their clinical significance and correlation with clinicopathological parameters.
The expression of Mena and Her-2 was detected in 40 breast cancer tissues and 14 normal breast tissues by immunohistochemistry, and the relationship of Mena and Her-2 expression with clinicopathological parameters was analyzed.
Both Mena (70%) and Her-2 (40%) were more commonly expressed in breast cancer than in normal breast tissue (7.1%, 0%, respectively; p < 0.05); further, Mena and Her-2 expression in breast cancer were positively correlated (r = 0.530, p < 0.05). In comparing expression with clinicopathological parameters of tumor samples, Mena and Her-2 were both associated with axillary lymph node metastasis and TNM stage (p < 0.05), but not with patient age or pathological type.
Mena and Her-2 are related to the malignancy degree and metastasis of breast cancer, and thus may play a coordinating role in the occurrence and progression of breast cancer.
本研究旨在确定Mena和Her-2在乳腺癌组织中的表达模式，并探讨它们的临床意义以及与临床病理参数的相关性。
采用免疫组织化学法检测40例乳腺癌组织和14例正常乳腺组织中Mena和Her-2的表达，并分析Mena和Her-2表达与临床病理参数的关系。
Mena（70%）和Her-2（40%）在乳腺癌中的表达均高于正常乳腺组织（分别为7.1%、0%；p<0.05）；此外，乳腺癌中Mena和Her-2的表达呈正相关（r=0.530，p<0.05）。在将表达与肿瘤样本的临床病理参数进行比较时，Mena和Her-2均与腋窝淋巴结转移和TNM分期相关（p<0.05），但与患者年龄或病理类型无关。
Mena和Her-2与乳腺癌的恶性程度和转移有关，因此可能在乳腺癌的发生和发展中起协同作用。
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