一项评估移动医疗系统监测和增强酒精使用障碍药物治疗依从性的随机试验。
A randomized trial evaluating an mHealth system to monitor and enhance adherence to pharmacotherapy for alcohol use disorders.
机构信息
Talaria, Inc, 1121 34th Ave, Seattle, WA 98122, USA.
出版信息
Addict Sci Clin Pract. 2012 Jun 8;7(1):9. doi: 10.1186/1940-0640-7-9.
BACKGROUND
Nonadherence to prescribed medication regimens is a substantial barrier to the pharmacological management of alcohol use disorders. The availability of low-cost, sustainable interventions that maximize medication adherence would likely lead to improved treatment outcomes. Mobile health (mHealth) technologies are increasingly being adopted as a method of delivering behavioral health interventions and represent a promising tool for adherence interventions. We are evaluating a cell-phone-based intervention called AGATE that seeks to enhance adherence with regular text-messaging.
METHODS/DESIGN: A randomized controlled effectiveness trial in the context of an eight-week open label naltrexone efficacy trial delivered in a naturalistic clinical setting. Treatment-seeking heavy drinkers (N = 105) are currently being recruited and randomly assigned to the AGATE intervention or a control condition. Daily measures of alcohol use and medication side effects are being recorded via cell phone in both conditions. Additionally, participants randomized to the AGATE condition receive medication reminders via SMS text message according to a schedule that adjusts according to their level of adherence.
DISCUSSION
Results from this trial will provide initial information about the feasibility and efficacy of mHealth interventions for improving adherence to alcohol pharmacotherapies.
TRIAL REGISTRATION
NCT01349985.
背景
不遵守规定的药物治疗方案是酒精使用障碍药物治疗的一个重大障碍。提供低成本、可持续的干预措施，最大限度地提高药物依从性，可能会改善治疗效果。移动健康（mHealth）技术越来越多地被用作提供行为健康干预措施的一种方法，并且是一种很有前途的依从性干预工具。我们正在评估一种基于手机的干预措施，称为 AGATE，旨在通过定期发送短信来提高依从性。
方法/设计：在自然临床环境中进行的为期八周的纳曲酮疗效开放标签试验的背景下进行的随机对照有效性试验。目前正在招募有治疗需求的重度饮酒者（N=105），并将他们随机分配到 AGATE 干预组或对照组。在这两种情况下，都通过手机记录每日饮酒量和药物副作用的测量。此外，随机分配到 AGATE 条件的参与者将根据他们的依从性水平按计划通过短信获得药物提醒。
讨论
该试验的结果将提供关于 mHealth 干预措施改善酒精药物治疗依从性的可行性和疗效的初步信息。
试验注册
NCT01349985。
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