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NF135.C10：一种用于人体疟疾感染的新型恶性疟原虫克隆。

NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections.

机构信息

Department of Medical Microbiology, Radboud University Nijmegen Medical Center, the Netherlands.

出版信息

J Infect Dis. 2013 Feb 15;207(4):656-60. doi: 10.1093/infdis/jis725. Epub 2012 Nov 27.

DOI:10.1093/infdis/jis725
PMID:23186785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3549599/
Abstract

UNLABELLED

We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. The Cambodian clone NF135.C10 consistently produced gametocytes and generated substantial numbers of sporozoites in Anopheles mosquitoes and diverged from NF54 parasites by genetic markers. In a controlled human malaria infection trial, 3 of 5 volunteers challenged by mosquitoes infected with NF135.C10 and 4 of 5 challenged with NF54 developed parasitemia as detected with microscopy. The 2 strains induced similar clinical signs and symptoms as well as cellular immunological responses.

CLINICAL TRIALS REGISTRATION

NCT01002833.

摘要

未加标签

我们建立了一个新的恶性疟原虫野外分离株，用于控制人体疟疾感染和疫苗研究，以补充目前主要基于 NF54 的少数恶性疟原虫株。柬埔寨分离株 NF135.C10 始终产生配子体，并在按蚊中产生大量的子孢子，且与 NF54 寄生虫通过遗传标记而分化。在一项控制人体疟疾感染试验中，经 NF135.C10 感染的蚊子感染的 5 名志愿者中的 3 名和经 NF54 感染的 5 名志愿者中的 4 名出现了显微镜可检测的寄生虫血症。这 2 个株系诱导了相似的临床体征和症状以及细胞免疫反应。

临床试验注册

NCT01002833。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a18/3549599/1824e2d621f4/jis72501.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a18/3549599/1824e2d621f4/jis72501.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a18/3549599/1824e2d621f4/jis72501.jpg

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