Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
Mucosal Immunol. 2013 Jul;6(4):787-96. doi: 10.1038/mi.2012.117. Epub 2012 Nov 28.
Despite near universal vaccine coverage, the bacterial pathogen Bordetella pertussis has re-emerged as a major public health concern. We recently developed a baboon (Papio anubis) model of pertussis that provides an excellent model of human pertussis. Using this model, the immune response to pertussis was characterized by measuring cytokines in the nasopharyngeal mucosa of infected baboons. Notably, we observed mucosal expression of interleukin-17 (IL-17) as well as IL-6, IL-23, and several cytokines and chemokines that are orchestrated by IL-17 immune responses. We also found substantial populations of circulating B. pertussis-specific Th17 and Th1 cells in convalescent animals >2 years post-infection consistent with a role in immunological memory to pertussis. Collectively, these data shed important light on the innate and adaptive immune responses to pertussis in a primate infection model and suggest that Th17 and Th1 immune responses contribute to the immunity conferred by natural pertussis infection.
尽管几乎普遍接种了疫苗，但细菌病原体百日咳博德特氏菌已重新成为一个主要的公共卫生关注点。我们最近开发了一种狒狒（Papio anubis）百日咳模型，该模型为人类百日咳提供了一个极好的模型。使用该模型，通过测量感染狒狒的鼻咽黏膜中的细胞因子来描述对百日咳的免疫反应。值得注意的是，我们观察到白细胞介素-17（IL-17）以及 IL-6、IL-23 和几种由 IL-17 免疫反应协调的细胞因子和趋化因子在鼻黏膜中的表达。我们还发现，在感染后>2 年的恢复期动物中，存在大量循环的百日咳特异性 Th17 和 Th1 细胞，这与在百日咳感染中发挥免疫记忆作用一致。总的来说，这些数据为灵长类动物感染模型中对百日咳的先天和适应性免疫反应提供了重要的启示，并表明 Th17 和 Th1 免疫反应有助于自然感染百日咳所赋予的免疫力。
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