Martinez-Aguirre E, Wikinski J
Acta Anaesthesiol Belg. 1979 Sep;30(3):183-8.
The intravenous injection of ketamine in the human arm with isolated circulation, using the same technique as for intravenous regional anesthesia, produces a dose-related depression of neuromuscular transmission, as evidenced by the evoked response to supramaximal stimulation of the ulnar nerve with a nerve stimulator. The dose range of ketamine was 200, 25, 10, 5, 1, 0.5 and 0.25 mg, in 20 ml of 5% dextrose in water. The exact mechanism of this effect is discussed. This depression may have clinical significance under certain circumstances.
采用与静脉区域麻醉相同的技术，在人体手臂进行隔离循环的情况下静脉注射氯胺酮，会产生与剂量相关的神经肌肉传递抑制，这可通过用神经刺激器对尺神经进行超强刺激所诱发的反应得到证明。氯胺酮的剂量范围为200、25、10、5、1、0.5和0.25毫克，溶于20毫升5%的葡萄糖水溶液中。文中讨论了这种效应的确切机制。在某些情况下，这种抑制可能具有临床意义。
