Suzuki T, Nagai H, Katsumata N, Ogawa S, Suzuki H
Department of Anesthesiology, University Hospital, Tokyo.
Masui. 1998 Dec;47(12):1433-6.
Neuromuscular inhibitory effects of propofol were investigated in 7 cats using muscular compound action potential (mCAP) elicited from the gastrocnemius muscle by sciatic nerve stimulation. A rectangular pulse of supramaximal strength and duration of 0.2 msec was applied serially to the sciatic nerve at 0.1 Hz during the experiments, and mCAPs obtained from the gastrocnemius muscle were recorded. After obtaining a constant mCAP amplitude, a series of 8 consecutive mCAPs (M 1-8) evoked by repetitive stimulation at 100 Hz was recorded, and M 8/M 1 amplitude ratio (M 8 amplitude/M 1 amplitude.100%) was calculated as the control value. After control variables had been obtained, initial dose of 2.5 mg.kg-1 of propofol was administered intravenously followed by continuous infusion with incremental dosages of 10, 20, 50 and 100 mg.kg-1.hr-1 of each 30 minute duration. The effects on mCAPs evoked by single and 8 consecutive repetitive stimulation were observed in each period. The depression of single mCAP amplitudes and fading responses in the M 8/M 1 amplitude ratios were not observed at any infusion rate. Our results suggest that propofol has no influence on neuromuscular transmission in cats when administered intravenously at 10 times of human clinical infusion doses.
使用坐骨神经刺激腓肠肌诱发的肌肉复合动作电位（mCAP），在7只猫身上研究了丙泊酚的神经肌肉抑制作用。实验期间，以0.1Hz的频率向坐骨神经连续施加强度为超强、持续时间为0.2毫秒的矩形脉冲，并记录从腓肠肌获得的mCAP。在获得稳定的mCAP幅度后，记录由100Hz重复刺激诱发的一系列8个连续的mCAP（M1-8），并计算M8/M1幅度比（M8幅度/M1幅度×100%）作为对照值。在获得对照变量后，静脉注射初始剂量为2.5mg·kg-1的丙泊酚，随后以每30分钟递增剂量10、20、50和100mg·kg-1·hr-1进行持续输注。在每个时间段观察对单次和8次连续重复刺激诱发的mCAP的影响。在任何输注速率下均未观察到单次mCAP幅度的降低和M8/M1幅度比中的衰减反应。我们的结果表明，当以人类临床输注剂量的10倍静脉注射丙泊酚时，其对猫的神经肌肉传递没有影响。
