Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea.
Jpn J Ophthalmol. 2013 Mar;57(2):156-65. doi: 10.1007/s10384-012-0190-z. Epub 2012 Nov 28.
To compare the correlation between optic disc rim area and retinal nerve fiber layer thickness (rim-RNFL correlation) in diabetic eyes with non-progressive RNFL defects and normal tension glaucoma (NTG) eyes.
Seventy-three eyes of 73 patients with preperimetric or early NTG and 25 eyes of 25 type II diabetes patients with a non-progressive RNFL defect for ≥5 years were enrolled in this retrospective cohort study. Rim areas and RNFL thicknesses were measured by Heidelberg retina tomography (HRT II) and by optical coherence tomography (Cirrus OCT), in global and 12 clock-hour parameters. Diabetic eyes were evaluated whether they were above the 95 % prediction interval (PI) for the rim-RNFL correlation of NTG.
A significant linear rim-RNFL correlation was observed in NTG eyes globally and at all clock-hours, except in the 4 and 9 o'clock areas, (0.08 < r (2) < 0.56, P < 0.05). Eighty-four percent of the diabetic eyes were above the 95 % PI of the rim-RNFL correlation of NTG in ≥2 clock-hours, as compared with 36 % of the eyes in the global parameter.
The eyes of diabetic patients with non-progressive RNFL were well-differentiated from NTG eyes by the rim-RNFL correlation.
比较伴有非进展性神经纤维层缺损的糖尿病眼与正常眼压性青光眼（NTG）眼视盘边缘区面积与视网膜神经纤维层厚度（边缘-RNFL 相关性）的相关性。
本回顾性队列研究纳入了 73 例眼压正常的前期或早期 NTG 患者的 73 只眼和 25 例 25 型糖尿病患者的 25 只眼，这些糖尿病患者的非进展性 RNFL 缺损持续时间≥5 年。使用海德堡视网膜断层扫描仪（HRT II）和光学相干断层扫描仪（Cirrus OCT）测量边缘区面积和 RNFL 厚度，包括全局和 12 个时钟小时参数。评估糖尿病眼是否超过 NTG 边缘-RNFL 相关性的 95%预测区间（PI）。
NTG 眼全局和所有时钟小时均存在显著的线性边缘-RNFL 相关性，除了 4 点和 9 点区域（0.08<r(2)<0.56，P<0.05）。84%的糖尿病眼在≥2 个时钟小时超过 NTG 边缘-RNFL 相关性的 95%PI，而全局参数中只有 36%的眼超过。
与 NTG 眼相比，具有非进展性 RNFL 的糖尿病患者的眼通过边缘-RNFL 相关性得到很好地区分。
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