Department of Ophthalmology and Visual Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
J Neurointerv Surg. 2013 Nov;5(6):e42. doi: 10.1136/neurintsurg-2012-010508.rep. Epub 2012 Nov 27.
We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.
我们介绍了一例经超选择性眼动脉内化疗治疗的视网膜母细胞瘤，通过 MRI 显示出所输注的化疗药物选择性地输送到肿瘤床。一名 7 个月大的婴儿患有 E 组（国际分类）单侧视网膜母细胞瘤。我们用几轮眼内动脉注射马法兰治疗该患者。马法兰中加入钆以显示这种化疗药物的分布。治疗后 15 分钟内进行术中 MRI 检查，显示肿瘤和视网膜下间隙增强。我们在此证明，超选择性眼动脉内给予化疗药物似乎可将药物输送到肿瘤和视网膜下间隙。
