Zhang Li-Dong, Xie Wei, Pei Jing, Zhao Dan
The Third Affiliated Hospital of Guangzhou Medical College's Obstetrics and Gynecology, Guangzhou 510150, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Aug;26(4):276-8.
Discussion of the relationship between cervical cytology and high-risk HPV test and lesions in the cervical tissue.
The 254 infertile patients were graded into 4 groups based on the results of cervical cytology and high-risk HPV test. The patients in group A were the cervical cytology -positive and HPV-positive. The cervical cytology -positive and HPV-negative patients were in group B. The cervical cytology -negative and HPV-positive patients were in group C and cervical cytology -negative and HPV-negative in group D. Retrospective analysis was used in the relationship between the results and lesions in the cervical tissue.
The incidence of CIN II and higher grade than CIN II was significant higher in group A than in group B (P < 0.01). The incidence of CIN I was no difference among A, B and C group (P > 0.05). The sensitivity was 100.0% and the specificity was 46.74% when cervical cytology was used to test the CIN II grade. But the sensitivity changed to 97.22% and the specificity 87.16% when both of the cervical cytology and HPV test were used.
The cervical cytology is the first choice in cervical examination. And the accuracy will significant higher when the HPV test is used simultaneously.
探讨宫颈细胞学检查与高危型人乳头瘤病毒（HPV）检测结果与宫颈组织病变之间的关系。
将254例不孕患者根据宫颈细胞学检查及高危型HPV检测结果分为4组。A组为宫颈细胞学检查阳性且HPV检测阳性；B组为宫颈细胞学检查阳性但HPV检测阴性；C组为宫颈细胞学检查阴性但HPV检测阳性；D组为宫颈细胞学检查阴性且HPV检测阴性。采用回顾性分析方法分析上述结果与宫颈组织病变之间的关系。
A组中宫颈上皮内瘤变（CIN）Ⅱ级及CINⅡ级以上病变的发生率显著高于B组（P<0.01）。A、B、C组中CINⅠ级病变的发生率差异无统计学意义（P>0.05）。单独采用宫颈细胞学检查诊断CINⅡ级病变时，灵敏度为100.0%，特异度为46.74%；同时采用宫颈细胞学检查及HPV检测时，灵敏度变为97.22%，特异度变为87.16%。
宫颈细胞学检查是宫颈病变检查的首选方法，联合HPV检测可显著提高诊断的准确性。
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