Zhang Li-dong, Pei Jing, Zhang Hui-min, Sun Xiao-fang
The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Oct;24(5):346-8.
Discussion of the relationship between Mycoplasma and chlamydia infection and lesions in the cervical tissue in high-risk HPV-positive infertile patients with cervical.
HPV-negative patients with cervical as the control, retrospective analysis the relationship of Mycoplasma hominis and chlamydia infection, cervical histological graded, and inflammation graded.
The rate of HPV infection in mycoplasma-positive and those with negative mycoplasma has significant difference (P < 0.01), The rate of HPV infection in chlamydia-positive and those with negative chlamydia has no significant difference (P > 0.05). CIN and the incidence of cervical erosion and CIN grade were higher in HPV-positive than HPV-negative group (P < 0.01). The cervical erosion of HPV-positive was no difference in the degree (P > 0.05). Compared with the simple HPV-positive group, CIN and the incidence of severe cervical erosion in mixed infection of Mycoplasma was no difference (P > 0.05).
Mycoplasma infection increases the rate of high risk HPV infection, high-risk HPV infection increased cervical pathological damage, Mycoplasma infection might be the factor of persistent infection with high risk HPV, the degree of cervical pathological is the factor of cervical infertility which can not be ignored.
探讨高危型人乳头瘤病毒（HPV）阳性的宫颈不孕患者中支原体和衣原体感染与宫颈组织病变之间的关系。
以HPV阴性的宫颈患者作为对照，回顾性分析解脲脲原体和衣原体感染、宫颈组织学分级以及炎症分级之间的关系。
支原体阳性组与支原体阴性组的HPV感染率有显著差异（P<0.01），衣原体阳性组与衣原体阴性组的HPV感染率无显著差异（P>0.05）。HPV阳性组的宫颈上皮内瘤变（CIN）、宫颈糜烂发生率及CIN分级均高于HPV阴性组（P<0.01），HPV阳性组的宫颈糜烂程度无差异（P>0.05）。与单纯HPV阳性组相比，支原体混合感染组的CIN及重度宫颈糜烂发生率无差异（P>0.05）。
支原体感染增加高危型HPV感染率，高危型HPV感染增加宫颈病理损害，支原体感染可能是高危型HPV持续感染的因素，宫颈病理程度是宫颈不孕不可忽视的因素。
