锰离子（Mn2+）与非自互补Z型DNA双链体的相互作用。
Interactions of Mn2+ with a non-self-complementary Z-type DNA duplex.
作者信息
Mandal P K, Venkadesh S, Gautham N
机构信息
CAS in Crystallography and Biophysics, University of Madras, Guindy, Chennai 600 025, India.
出版信息
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1420-6. doi: 10.1107/S1744309112041759. Epub 2012 Nov 14.
Abstract
Crystal structures of the hexanucleotide d(CACGCG)·d(CGCGTG) were determined in two crystal lattices when different concentrations of the counterion Mn2+ were used in crystallization. The availability of Mn2+ during the crystallization process appears to play an important role in inducing different crystal packings that lead to crystals belonging to the two space groups P2(1) and P6(5). Analysis of the molecular interactions of Mn2+ with the Z-form duplexes shows direct coordination to the purine residues G and A.
摘要
当在结晶过程中使用不同浓度的抗衡离子Mn2+时，在两个晶格中测定了六核苷酸d（CACGCG）·d（CGCGTG）的晶体结构。结晶过程中Mn2+的可用性似乎在诱导不同的晶体堆积中起重要作用，这些堆积导致晶体属于两个空间群P2(1)和P6(5)。对Mn2+与Z型双链体的分子相互作用分析表明，Mn2+与嘌呤残基G和A直接配位。
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