六氨合钌（III）离子与Z-DNA的相互作用。
Hexammineruthenium(III) ion interactions with Z-DNA.
作者信息
Bharanidharan D, Thiyagarajan S, Gautham N
机构信息
Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.
出版信息
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1008-13. doi: 10.1107/S1744309107047781. Epub 2007 Nov 21.
Abstract
The hexamer duplex d(CGCGCA).d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity.
摘要
六聚体双链体d（CGCGCA）.d（TGCGCG）与六氨合钌（III）离子在正交空间群中结晶；晶体衍射分辨率达到1.54 Å。与腺嘌呤碱基的强离子相互作用诱导了从氨基形式到亚氨基形式的互变异构转变。因此，A.T碱基对被破坏。这项结构研究可能与金属毒性有关。
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