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六氨合钌（III）离子与Z-DNA的相互作用。

Hexammineruthenium(III) ion interactions with Z-DNA.

作者信息

Bharanidharan D, Thiyagarajan S, Gautham N

机构信息

Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.

出版信息

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1008-13. doi: 10.1107/S1744309107047781. Epub 2007 Nov 21.

DOI:10.1107/S1744309107047781
PMID:18084080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2344113/
Abstract

The hexamer duplex d(CGCGCA).d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity.

摘要

六聚体双链体d（CGCGCA）.d（TGCGCG）与六氨合钌（III）离子在正交空间群中结晶；晶体衍射分辨率达到1.54 Å。与腺嘌呤碱基的强离子相互作用诱导了从氨基形式到亚氨基形式的互变异构转变。因此，A.T碱基对被破坏。这项结构研究可能与金属毒性有关。

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本文引用的文献

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Deamination of Adenine by Ionizing Radiation.腺嘌呤的致电离辐射脱氨作用。
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2
Structure of d(TGCGCG).d(CGCGCA) in two crystal forms: effect of sequence and crystal packing in Z-DNA.两种晶体形式下d(TGCGCG).d(CGCGCA)的结构：序列和晶体堆积对Z-DNA的影响
Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1125-31. doi: 10.1107/S0907444905016781. Epub 2005 Jul 20.
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Cobalt hexammine induced tautomeric shift in Z-DNA: the structure of d(CGCGCA)*d(TGCGCG) in two crystal forms.六氨合钴诱导Z-DNA中的互变异构移位：两种晶体形式的d(CGCGCA)*d(TGCGCG)的结构
Nucleic Acids Res. 2004 Nov 8;32(19):5945-53. doi: 10.1093/nar/gkh919. Print 2004.
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Refinement of macromolecular structures by the maximum-likelihood method.用最大似然法优化大分子结构。
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3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures.3DNA：一个用于三维核酸结构分析、重建和可视化的软件包。
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