Academic Medical Centre, Department of Hospital Pharmacy, Amsterdam, the Netherlands; ApoMed, Amsterdam, the Netherlands.
Pharmacoepidemiol Drug Saf. 2013 Apr;22(4):423-9. doi: 10.1002/pds.3373. Epub 2012 Nov 29.
Crushing solid oral dosage forms is an important risk factor for medication administration errors (MAEs) in patients with swallowing difficulties. Nursing home (NH) residents, especially those on psychogeriatric wards, have a high prevalence of such difficulties.
Six different psychogeriatric wards in two Dutch NH facilities, participating over a total period of 1 year divided into preintervention, implementation, and the first and second evaluation period.
Number of MAEs per number of observed medication administrations calculated for all and three subtypes of MAEs: crushing-uncrushable-medication, inappropriate-technique, and food-drug interactions.
The intervention included (i) education for nursing staff about crushing medication safely, (ii) a medication administration protocol for patients with swallowing difficulties, (iii) a 'do-not-crush-medication' pocket card for the nursing staff, (iv) screening of medication charts by pharmacy technicians on potential crushing problems, and (v) advices on medication charts on safe medication administration to residents with swallowing problems.
The number of crushing uncrushable medication errors, an MAE subtype with the highest potential risk for patient harm, was reduced significantly from 19 (9.6%) to 7 (3.0%; first evaluation period), adjusted odds ratio 0.20 (OR = 95%CI, 0.07-0.55). During the second evaluation period, the proportion crushing uncrushable medications errors was the only outcome that remained significantly lower in comparison with the preintervention period (p = 0.045).
Introduction of a multifaceted medication safety programme in NH facilities by a pharmacy team is a tool towards safer medication administration practice in residents with swallowing difficulties. Commitment on organisational level is, however, vital to achieve sustainable improvements.
压碎固体口服剂型是吞咽困难患者用药错误(MAE)的一个重要危险因素。养老院(NH)居民,尤其是那些在精神科病房的患者,吞咽困难的发生率很高。
荷兰两家 NH 设施的六间不同的精神科病房,参与了为期一年的总时间,分为干预前、实施和第一和第二评估期。
所有观察到的给药次数中 MAE 的数量,以及三种 MAE 亚型(压碎不可压碎药物、不当技术和食物药物相互作用)的数量。
干预措施包括(i)对护理人员进行安全压碎药物的教育,(ii)为吞咽困难患者制定药物管理方案,(iii)为护理人员制作“不要压碎药物”口袋卡,(iv)药剂师对药物图表进行潜在压碎问题筛查,以及(v)对有吞咽问题的居民的药物图表上提供安全给药的建议。
压碎不可压碎药物错误的数量,一种对患者危害风险最高的 MAE 亚型,从 19(9.6%)显著减少到 7(3.0%;第一评估期),调整后的比值比 0.20(OR=95%CI,0.07-0.55)。在第二评估期,与干预前相比,压碎不可压碎药物错误的比例仍然显著较低(p=0.045)。
药剂团队在 NH 设施中引入多方面的药物安全计划是实现吞咽困难患者更安全的药物管理实践的工具。然而,组织层面的承诺对于实现可持续的改进至关重要。